SFB 1177

Molecular and Functional Characterization of Selective Autophagy

Autophagy is a highly conserved catabolic process that serves as a quality control mechanism in cells by selectively removing damaged and superfluous organelles or other harmful cytosolic material, such as aggregated proteins or invaded bacteria. Under stress or energy restriction autophagy provides recycled building blocks for the synthesis of new cellular components. Three different types of autophagy can be distinguished: macroautophagy, microautophagy and chaperone-mediated autophagy. This SFB focuses on macroautophagy (hereafter referred to as autophagy), a multi-step cellular process by which cytosolic material is engulfed by a double-membrane, termed autophagosome after closure, which eventually fuses with a lysosome in order to eliminate its content. Autophagy plays a vital role in protecting against disease, but in recent years it became clear that the effect of autophagy is highly contextual. While it acts for instance as an anti-tumorigenic mechanism in healthy cells, cancer cells exploit the cytoprotective effect of autophagy to overcome stress conditions and nutrient limitation caused by rapid tumor growth. SFB 1177 aims at gaining a more detailed insight into the mechanistic details of autophagic pathways to better understand its role in disease development and eventually exploit this knowledge therapeutically.

 

Funded by DFG

Contact

 

Speaker: Prof. Dr. Ivan Dikic Ivan Dikic
IBC2 Uniklinik | BMLS, Goethe University
Send an Email to Ivan Dikic
Website of Prof. Ivan dikic

Vice-Speaker: Prof. Dr. Christian BehlChristian Behl
Universitätsmedizin der JGU Mainz
Send an Email to Christian BehlWebsite of Prof. Ivan dikic

Coordinator: Dr. Heide GenauHeide Genau
Phone: +49 69/6301-84832
Send an Email to Heide GenauWebsite of Prof. Ivan dikic

Activities and News

 

Interview with Christian Behrends, project leader in SFB 1177

Journal of Cell Science JCS interview


Interested in Alzheimer’s - register here: "Beyond Amyloid - Widening the View on Alzheimer's Disease“

Herrenhausen Symposium, October 10 & 11 in Hanover, Germany.
Hosted as a Herrenhausen Symposium by the Volkswagen Foundation the meeting aims at bringing together current knowledge on molecular and cellular processes that contribute to AD pathogenesis beyond the so far dominating amyloid hypothesis and at fostering discussion on future perspectives in AD research. Topics to be covered include inflammation, vascular dysfunction, mitochondrial integrity, cell cycle events, lipid metabolism, tau biochemistry, protein misfolding and autophagy. There are no fees to attend the symposium but registration is required.
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