TopPic
  • Activities and News
  • Publications

New Editor-in-Chief of American Journal of Physiology-Cell Physiology: Liliana Schaefer

07. Jun 2021

Image: news/schaefer.jpg

Starting in July 2021, Professor Dr. Liliana Schaefer will take over the new Editor-in-Chief of the American Journal of Physiology-Cell Physiology.

Dr. Schaefer is an expert in Matrix biology, Pharmacology and Nephropharmacology and has contributed significantly to the field of Physiology by unraveling that two components of the extracellular matrix, decorin and biglycan, act as endogenous “danger” signals when in soluble form in the blood and body fluids.

She is a Professor of Pharmacology at the Institute of Pharmacology and Toxicology, Goethe University in Frankfurt, Germany and Adjunct Research Professor of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, USA. In addition, Liliana Schaefer has been PI of SFB 1177 since the first funding period in 2016 and is currently represented with her E02-project “Selective autophagy network in diabetic nephropathy”.




Follow on Twitter | IBCII

New Editor-in-Chief for Journal of Cellular Biochemistry: Christian Behl

04. Dec 2020

Image: news/jcb-behl-2.png

In summer 2020, Christian Behl took over the task of new Editor-in-Chief of the Journal of Cellular Biochemistry (Wiley). Together with the newly established editorial board (including now Christian Münch), a renewal of the Aims and Scope was implemented and the Author Guidelines and Data Reporting Policy were strictly adapted in order to ensure quality standards.
In the near future, Christian Behl intends to also promote special issues on SFB 1177-relevant topics such as autophagy, quality control and many more. In additon, he highly encourages the consortium members to submit original papers and reviews to the Journal of Cellular Biochemistry - a fair, objective, high quality and timely review process is guaranteed. For any related questions feel free to contact Christian anytime (cbehl@uni-mainz.de).

Christian Behl is Director of the Institute for Pathobiochemistry at the University Medical Center of the Johannes Gutenberg University Mainz, Vice Speaker of SFB 1177 since 2016 and project leader of the E04-project on BAG3-mediated selective autophagy in neuronal protein homeostasis and neurodegeneration. 


Downloads:
  1. Announcement


Follow on Twitter | IBCII

Ivan Đikić honored as Highly Cited Researcher 2020

18. Nov 2020

Image: news/cuthighly-cited-researcher-award.jpg

For the third year in a row, IBC2 Director Ivan Đikić is recognized as one of the pioneers in his field on Clarivate’s Highly Cited Researchers list. His papers rank in the top 1% by citations in the field of “Molecular Biology & Genetics”. In previous years, he was honored for his exceptional performance in the “Molecular Biology & Genetics” and the “Cross-Field” sections.

The highly anticipated annual list identifies pioneers in the respective fields who demonstrated significant and broad influence by publishing multiple highly cited papers during the last decade. Their names are drawn from the publications that rank in the top 1% by citations for field and publication year in the Web of Science citation index. The papers analyzed were published between 2009 and 2019.
Approximately 6,000 researchers worldwide are named in this years’ list, 345 of them are based in Germany. Besides Ivan Đikić, seven other colleagues from Goethe University have been credited. The global pole position is traditionally taken by Harvard University.




Follow on Twitter | IBCII

Münch group describes potential COVID-19 therapies

13. May 2020

Image: news/covid-19.png

Despite COVID-19 quickly developing to a world-wide pandemic, treatment options remain limited. The mechanisms by which SARS-CoV-2 enters cells, how the cell responds to infection, and which therapeutic approaches could stop viral replication remain unclear. In a manuscript published today in the renowned journal Nature, IBC2 group leader Christian Münch, together with Jindrich Cinatl (Institute of Medical Virology, University Hospital Frankfurt), provide with answers to these questions. Using SARS-CoV-2 isolated from COVID-19 patients in Frankfurt, they established a cellular model to study coronavirus infection. Using a recently developed novel translation proteomics method (https://doi.org/10.1016/j.molcel.2019.11.010), they analysed how viral infection changes cellular protein synthesis and abundance. This revealed several cellular pathways strongly modulated upon SARS-CoV-2 infection. Strikingly, using drugs targeting these pathways – some of which are approved for use in other diseases – prevented SARS-CoV-2 replication in cells. This reveals potential new therapeutic strategies for specific COVID-19 treatments and have been picked up for ongoing (ribavirin) and planned (2-deoxy-glucose) clinical trials.




Follow on Twitter | IBCII

Successful prolongation of SFB 1177

25. Nov 2019

Image: news/sfb-1177-logo-1-.gif

We are very happy to announce that the German Research Foundation (DFG) will fund this SFB for another four years with >12 M €. This enables us to continue the ambitious and highly integrative work program to better understand the mechanistic regulation of autophagy networks in health and disease. With most projects critically depending on state-of-the-art technologies, a key part of the 2nd funding proposal relates to the substantial expansion of the central platforms. Besides extending the existing quantitative proteomics unit to include modeling and simulation methods, the consortium will also establish new platforms for genomic and chemical screening and for quantitative phenotype analysis. To close the gap on missing expertise, the team was also significantly enlarged, and we welcome all new colleagues from the Universities of Mainz, Tübingen and Freiburg and the Max Planck Institute of Biophysics on board!




Follow on Twitter | IBCII

A day of German-US scientific exchange on neurodegeneration and autophagy

Initiated by SFB 1177 Vice Speaker Christian Behl

24. Oct 2019

Image: news/cb-ny.png

A small group of experts and early-career researches met in New York to exchange latest results and views on „Alzheimer’s, Related Disorders and Autophagy“. So far, researchers worldwide have not been successful to unravel the mechanisms underlying neurodegenerative diseases. More recently, malfunctioning autophagy-related processes have been discussed as a possible cause. On this occasion, among others, SFB 1177 Speaker Ivan Dikic and Vice Speaker Christian Behl presented their latest data to the audience. The scientific workshop was followed by an evening session with more general discussions on future perspectives of Alzheimer’s treatment.

The event was organized by Christian Behl (University Medical Center of the Johannes Gutenberg University Mainz) and Ralph Nixon (Nathan S. Kline Institute for Psychiatry, NYU Langone Medical Center) in cooperation with the German Center for Research and Innovation (DWIH, New York). It was funded by the Dr. Eberhard Strebel-Stiftung and the University Medical Center of the Johannes Gutenberg University in Mainz.




Follow on Twitter | IBCII

2021

Heinz D, Krotova E, Hamann A, Osiewacz HD. 2021. Simultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension. Front Cell Dev Biol. vol.9, 259. https://doi.org/10.3389/fcell.2021.616520

Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Münch C, Fulda S, Tegeder I, Kögel D. 2021. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy

A Network of Pathways Controlling Cellular Homeostasis Affects the Onset of Senescence in Podospora anserina. J. Fungi, 7(4), 263. https://doi.org/10.3390/jof7040263

Seibert M, Kurrle N, Schnütgen F, Serve H. 2021. Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation. Matrix Biol. doi: 10.1016/j.matbio.2021.01.001.

Warnsmann V, Marschall LM, Osiewacz HD. 2021. Impaired F1Fo-ATP-Synthase Dimerization Leads to the Induction of Cyclophilin D-Mediated Autophagy-Dependent Cell Death and Accelerated Aging. Cells, 10, 757. https://doi.org/10.3390/cells10040757

2020

Barz S, Kriegenburg F, Henning A, Bhattacharya A, Mancilla H, Sánchez-Martín P, & Kraft C. 2020. Atg1 kinase regulates autophagosome-vacuole fusion by controlling SNARE bundling. EMBO reports, 21(12), e51869.

Eickhorst C, Licheva M, Kraft C. 2020. Scaffold proteins in bulk and selective autophagy. Prog Mol Biol Transl Sci. 2020;172:15-35.
Glogger M, Spahn C, Enderlein J, Heilemann M. 2020. Multi-Color, Bleaching-Resistant Super-Resolution Optical Fluctuation Imaging with Oligonucleotide-based Exchangeable Fluorophores. Angew Chem Int Ed Engl. https://doi.org/10.1002/anie.202013166

Henkel V, Schürmanns L, Brunner M, Hamann A, Osiewacz HD. 2020. Role of sorting nexin PaATG24 in autophagy, aging and development of Podospora anserina. Mech Aging Dev, 186:111211

Hollenstein DM, Kraft C. 2020. Autophagosomes are formed at a distinct cellular structure. Curr Opin Cell Biol. 2020;65:50-57.

Kern A, Behl C. 2020. On-demand autophagic network adaptations upon limited lipid availability. Autophagy, 16:7, 1348-1350

Kinzler MN, Zielke S, Kardo S, Meyer N, Kögel D, van Wijk SJL, Fulda S. 2020. STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts. Sci Rep 10, 687

Kögel D, Linder B, Brunschweiger A, Chines S, Behl C. 2020. At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer. Cells, 9(3), 574.

Steinberg R, Origi A, Natriashvili A, Sarmah P, Licheva M, Walker PM, Kraft C, High S, Luirink J, Shi WQ, Helmstädter M, Ulbrich MH, Koch HG. 2020. Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle. PLoS Biol. 18(9), e3000874.

Wesch N, Kirkin V, Rogov V.V. 2020. Atg8-Family Proteins-Structural Features and Molecular Interactions in Autophagy and Beyond. Cells, 9:9, E2008

Wiechmann S, Maisonneuve P, Grebbin BM, Hoffmeister M, Kaulich M, Clevers H, Rajalingam K, Kurinov I, Farin HF, Sicheri F, Ernst A. 2020. Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J Biol Chem. pii: jbc.RA119.011025.

Zein L, Fulda S, Kögel D, & van Wijk S. 2020. Organelle-specific mechanisms of drug-induced autophagy-dependent cell death. Matrix Biol. https://doi.org/10.1016/j.matbio.2020.12.003

Zielke S, Kardo S, Zein L, Mari M, Covarrubias-Pinto A, Kinzler MN, Meyer N, Stolz A, Fulda S, Reggiori F, Kögel D, van Wijk S. 2020. ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy, 1-17

2019

Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, Ren H, Lambert LJ, Cosford NDP, Brandts CH & Knapp S. 2019. Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Biochem J, 476, 875-887.

Chakraborty D, Felzen V, Hiebel C, Stuerner E, Perumal N, Manicam C, Grus F, Wolfrum U, Behl C. 2019. Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress. Redox Biol, accepted

Christ MG, Huesmann H, Nagel H, Kern A & Behl C. 2019. Sigma-1 receptor activation induces autophagy and increases proteostasis capacity in vitro and in vivo. Cells, 8, pii: E211

Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M, Settembre C. 2019. A selective ER-phagy exerts procollagen quality control via a Calnexin- FAM134B complex. EMBO J, 38, pii:299847

Fottner M, Brunner AD, Bittl V, Horn-Ghetko, Jussupow A, Kaila VRI, Bremm A & Lang K. 2019. Sitespecific ubiquitylation and SUMOylation

Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Guentert P, Dikic I, Kirkin V, Komatsu M, Dötsch V, Rogov VV. 2019. An atypical LIR motif within UFM1-activating enzyme 5 (UBA5) reveals an alternative function for GABARAP proteins. Autophagy, accepted.

Juretschke T, Beli P & Dikic I. 2019. Quantitative phosphoproteomics of selective autophagy receptors. pages 691–701, In: Autophagy; Methods in Molecular Biology. Vol. 1880 (eds. Ktistakis N and Florey O). Humana Press, New York.

Key J, Mueller AK, Gispert S, Matschke L, Wittig I, Corti O, Muench C, Decher N, Auburger G. 2019. Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons. Neurobiol Dis, 127, 114- 130.

Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krueger M, Benedito R, Dikic I. Potente M. 2019. Deubiquitinase USP10 regulates Notch signaling in the endothelium. Science, 364, 188-193.

Nguyen TD, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH. 2019. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Blood, 133, 168-179.

Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LTH, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Muench C, Dikic I, Brandts C, Iozzo RV, Wygrecka M & Schaefer L. 2019. Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis: Impact on renal ischemia/reperfusion injury. Kidney Int, 95, 540- 562

Roedig H, Nastase MV, Wygrecka M & Schaefer L. 2019. Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy. FEBS J, doi: 10.1111/febs.14791

Van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger, Trümbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF. 2019. A protein quality control pathway regulated by linear ubiquitination. EMBO J, pii: e100730.

Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M. 2019. Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. eLife, 8, pii: e42549.

2018

Di Rita A, Peschiaroli A, D Acunzo P, Strobbe D, Hu Z, Gruber J, Nygaard M, Lambrughi M, Melino G, Papaleo E, Dengjel J, El Alaoui S, Campanella M, Dötsch V, Rogov VV, Strappazzon F, Cecconi F. HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα. Nat Commun. 2018 Sep 14;9(1):3755. doi: 10.1038/s41467-018-05722-3. PubMed PMID: 30217973; PubMed Central PMCID: PMC6138665.

Kniss A, Kazemi S, Löhr F, Berger M, Rogov VV, Güntert P, Sommer T, Jarosch E, Dötsch V. Structural investigation of glycan recognition by the ERAD quality control lectin Yos9. J Biomol NMR. 2018 Jul 31. doi: 10.1007/s10858-018-0201-6. [Epub ahead of print] PubMed PMID: 30066206.

Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, Münch C, Behrends C, Kögel D. AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy. 2018;14(10):1693-1709. doi: 10.1080/15548627.2018.1476812. Epub 2018 Jul 21. PubMed PMID: 29938581; PubMed Central PMCID: PMC6135628.

Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM. A multiprotein supercomplex controlling oncogenic signalling in lymphoma. Nature. 2018 Aug;560(7718):387-391. doi: 10.1038/s41586-018-0290-0. Epub 2018 Jun 20. PubMed PMID: 29925955.

Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR. Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. Cell. 2018 Jun 28;174(1):88-101.e16. doi: 10.1016/j.cell.2018.05.028. Epub 2018 Jun 14. PubMed PMID: 29909986.

Kern A, Spang N, Huesmann H, Behl C. Novel Modulators of Proteostasis: RNAi Screen of Chromosome I in a Heat Stress Paradigm in C. elegans. Cells. 2018 May 26;7(6). pii: E49. doi: 10.3390/cells7060049. PubMed PMID: 29861461; PubMed Central PMCID: PMC6025327.

Roedig H, Nastase MV, Frey H, Moreth K, Zeng-Brouwers J, Poluzzi C, Hsieh LT, Brandts C, Fulda S, Wygrecka M, Schaefer L. Biglycan is a new high-affinity ligand for CD14 in macrophages. Matrix Biol. 2018 May 17. pii: S0945-053X(18)30186-0. doi: 10.1016/j.matbio.2018.05.006. [Epub ahead of print] PubMed PMID: 29777767.

Harwardt MIE, Dietz MS, Heilemann M, Wohland T. SPT and Imaging FCS Provide Complementary Information on the Dynamics of Plasma Membrane Molecules. Biophys J. 2018 May 22;114(10):2432-2443. doi: 10.1016/j.bpj.2018.03.013. Epub 2018 Apr 9. PubMed PMID: 29650369; PubMed Central PMCID: PMC6129459.

Dikic I, Elazar Z. Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364. doi: 10.1038/s41580-018-0003-4. Review. PubMed PMID: 29618831.

Kunz K, Piller T, Müller S. SUMO-specific proteases and isopeptidases of the SENP family at a glance. J Cell Sci. 2018 Mar 20;131(6). pii: jcs211904. doi: 10.1242/jcs.211904. Review. PubMed PMID: 29559551.

Fulda S. Targeting autophagy for the treatment of cancer. Biol Chem. 2018 Jun 27;399(7):673-677. doi: 10.1515/hsz-2018-0105. PubMed PMID: 29500917.

Heidelberger JB, Voigt A, Borisova ME, Petrosino G, Ruf S, Wagner SA, Beli P. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. EMBO Rep. 2018 Apr;19(4). pii: e44754. doi: 10.15252/embr.201744754. Epub 2018 Feb 21. PubMed PMID: 29467282; PubMed Central PMCID: PMC5891417.

Das CK, Linder B, Bonn F, Rothweiler F, Dikic I, Michaelis M, Cinatl J, Mandal M, Kögel D. BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells. Neoplasia. 2018 Mar;20(3):263-279. doi: 10.1016/j.neo.2018.01.001. Epub 2018 Feb 22. PubMed PMID: 29462756; PubMed Central PMCID: PMC5852393.

Kniss A, Schuetz D, Kazemi S, Pluska L, Spindler PE, Rogov VV, Husnjak K, Dikic I, Güntert P, Sommer T, Prisner TF, Dötsch V. Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains. Structure. 2018 Feb 6;26(2):249-258.e4. doi: 10.1016/j.str.2017.12.011. Epub 2018 Jan 18. PubMed PMID: 29358025.

Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte-Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F. Guidelines and recommendations on yeast cell death nomenclature. Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review. PubMed PMID: 29354647; PubMed Central PMCID: PMC5772036.

Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, Schaefer L. Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity. J Histochem Cytochem. 2018 Apr;66(4):213-227. doi: 10.1369/0022155417740880. Epub 2018 Jan 1. PubMed PMID: 29290139; PubMed Central PMCID: PMC5958376.

Nastase MV, Janicova A, Roedig H, Hsieh LT, Wygrecka M, Schaefer L. Small Leucine-Rich Proteoglycans in Renal Inflammation: Two Sides of the Coin. J Histochem Cytochem. 2018 Apr;66(4):261-272. doi: 10.1369/0022155417738752. Epub 2018 Jan 1. PubMed PMID: 29290137; PubMed Central PMCID: PMC5958374.

2017

Nastase MV, Zeng-Brouwers J, Wygrecka M, Schaefer L. Targeting renal fibrosis: Mechanisms and drug delivery systems. Adv Drug Deliv Rev. 2018 Apr;129:295-307. doi: 10.1016/j.addr.2017.12.019. Epub 2017 Dec 27. Review. PubMed PMID: 29288033.

Nastase MV, Zeng-Brouwers J, Beckmann J, Tredup C, Christen U, Radeke HH, Wygrecka M, Schaefer L. Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney. Matrix Biol. 2018 Aug;68-69:293-317. doi: 10.1016/j.matbio.2017.12.002. Epub 2017 Dec 15. PubMed PMID: 29253517.

Grumati P, Dikic I. Ubiquitin signaling and autophagy. J Biol Chem. 2018 Apr 13;293(15):5404-5413. doi: 10.1074/jbc.TM117.000117. Epub 2017 Nov 29. Review. PubMed PMID: 29187595; PubMed Central PMCID: PMC5900779.

Le Guerroué F, Eck F, Jung J, Starzetz T, Mittelbronn M, Kaulich M, Behrends C. Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell. 2017 Nov 16;68(4):786-796.e6. doi: 10.1016/j.molcel.2017.10.029. PubMed PMID: 29149599.

Jung J, Behrends C. Protocol for Establishing a Multiplex Image-based Autophagy RNAi Screen in Cell Cultures. Bio Protoc. 2017 Sep 5;7(17):27982478. doi: 10.21769/BioProtoc.2540. PubMed PMID: 28966949; PubMed Central PMCID: PMC5619641.

Varga J, Greten FR. Cell plasticity in epithelial homeostasis and tumorigenesis. Nat Cell Biol. 2017 Oct;19(10):1133-1141. doi: 10.1038/ncb3611. Epub 2017 Sep 25. Review. PubMed PMID: 28945230.

Harwardt MIE, Young P, Bleymüller WM, Meyer T, Karathanasis C, Niemann HH, Heilemann M, Dietz MS. Membrane dynamics of resting and internalin B-bound MET receptor tyrosine kinase studied by single-molecule tracking. FEBS Open Bio. 2017 Aug 29;7(9):1422-1440. doi: 10.1002/2211-5463.12285. eCollection 2017 Sep. PubMed PMID: 28904870; PubMed Central PMCID: PMC5586345.

Henkel V, Warnsmann V, Osiewacz HD. Autophagic responses compensate mitochondrial impairments. Aging (Albany NY). 2017 Sep 12;9(9):1947-1948. doi: 10.18632/aging.101292. PubMed PMID: 28904241; PubMed Central PMCID: PMC5636663.

Aguilera-Gomez A, Zacharogianni M, van Oorschot MM, Genau H, Grond R, Veenendaal T, Sinsimer KS, Gavis EA, Behrends C, Rabouille C. Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation. Cell Rep. 2017 Aug 29;20(9):2277. doi: 10.1016/j.celrep.2017.08.054. PubMed PMID: 28854374.

Schwalm S, Beyer S, Frey H, Haceni R, Grammatikos G, Thomas D, Geisslinger G, Schaefer L, Huwiler A, Pfeilschifter J. Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction. Am J Pathol. 2017 Nov;187(11):2413-2429. doi: 10.1016/j.ajpath.2017.06.017. Epub 2017 Aug 12. PubMed PMID: 28807595.

Reilly R, Mroz MS, Dempsey E, Wynne K, Keely SJ, McKone EF, Hiebel C, Behl C, Coppinger JA. Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis. Sci Rep. 2017 Aug 9;7(1):7642. doi: 10.1038/s41598-017-06588-z. PubMed PMID: 28794469; PubMed Central PMCID: PMC5550428.

Wiechmann S, Gärtner A, Kniss A, Stengl A, Behrends C, Rogov VV, Rodriguez MS, Dötsch V, Müller S, Ernst A. Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation. J Biol Chem. 2017 Sep 15;292(37):15340-15351. doi: 10.1074/jbc.M117.794255. Epub 2017 Aug 7. PubMed PMID: 28784659; PubMed Central PMCID: PMC5602394.

Polajnar M, Dietz MS, Heilemann M, Behrends C. Expanding the host cell ubiquitylation machinery targeting cytosolic Salmonella. EMBO Rep. 2017 Sep;18(9):1572-1585. doi: 10.15252/embr.201643851. Epub 2017 Aug 6. PubMed PMID: 28784601; PubMed Central PMCID: PMC5579355.

Jung J, Behrends C. Multifaceted role of SMCR8 as autophagy regulator. Small GTPases. 2017 Jul 11:1-9. doi: 10.1080/21541248.2017.1346553. [Epub ahead of print] PubMed PMID: 28696821.

Warnsmann V, Meyer N, Hamann A, Kögel D, Osiewacz HD. A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction. Mech Ageing Dev. 2018 Mar;170:45-58. doi: 10.1016/j.mad.2017.06.004. Epub 2017 Jul 3. PubMed PMID: 28684269.

Stürner E, Behl C. The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease. Front Mol Neurosci. 2017 Jun 21;10:177. doi: 10.3389/fnmol.2017.00177. eCollection 2017. Review. PubMed PMID: 28680391; PubMed Central PMCID: PMC5478690.

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG. Structural and functional analysis of the GABARAP interaction motif (GIM). EMBO Rep. 2017 Aug;18(8):1382-1396. doi: 10.15252/embr.201643587. Epub 2017 Jun 27. PubMed PMID: 28655748; PubMed Central PMCID: PMC5538626.

Grumati P, Morozzi G, Hölper S, Mari M, Harwardt MI, Yan R, Müller S, Reggiori F, Heilemann M, Dikic I. Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy. Elife. 2017 Jun 15;6. pii: e25555. doi: 10.7554/eLife.25555. PubMed PMID: 28617241; PubMed Central PMCID: PMC5517149.

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G. Molecular definitions of autophagy and related processes. EMBO J. 2017 Jul 3;36(13):1811-1836. doi: 10.15252/embj.201796697. Epub 2017 Jun 8. Review. PubMed PMID: 28596378; PubMed Central PMCID: PMC5494474.

Nastase MV, Janicova A, Wygrecka M, Schaefer L. Signaling at the Crossroads: Matrix-Derived Proteoglycan and Reactive Oxygen Species Signaling. Antioxid Redox Signal. 2017 Oct 20;27(12):855-873. doi: 10.1089/ars.2017.7165. Epub 2017 Jul 5. Review. PubMed PMID: 28510506.

van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I. Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation. Nat Microbiol. 2017 May 8;2:17066. doi: 10.1038/nmicrobiol.2017.66. PubMed PMID: 28481361. Dikic I. Proteasomal and Autophagic Degradation Systems. Annu Rev Biochem. 2017 Jun 20;86:193-224. doi: 10.1146/annurev-biochem-061516-044908. Epub 2017 May 1. Review. PubMed PMID: 28460188.

Knuppertz L, Osiewacz HD. Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan. Aging Cell. 2017 Aug;16(4):704-715. doi: 10.1111/acel.12600. Epub 2017 Apr 27. PubMed PMID: 28449241; PubMed Central PMCID: PMC5506401.

Rogov VV, Suzuki H, Marinković M, Lang V, Kato R, Kawasaki M, Buljubašić M, Šprung M, Rogova N, Wakatsuki S, Hamacher-Brady A, Dötsch V, Dikic I, Brady NR, Novak I. Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins. Sci Rep. 2017 Apr 25;7(1):1131. doi: 10.1038/s41598-017-01258-6. PubMed PMID: 28442745; PubMed Central PMCID: PMC5430633.

Knuppertz L, Warnsmann V, Hamann A, Grimm C, Osiewacz HD. Stress-dependent opposing roles for mitophagy in aging of the ascomycete Podospora anserina. Autophagy. 2017 Jun 3;13(6):1037-1052. doi: 10.1080/15548627.2017.1303021. Epub 2017 Apr 3. PubMed PMID: 28368682; PubMed Central PMCID: PMC5486364.

Philipp O, Hamann A, Osiewacz HD, Koch I. The autophagy interaction network of the aging model Podospora anserina. BMC Bioinformatics. 2017 Mar 27;18(1):196. doi: 10.1186/s12859-017-1603-2. PubMed PMID: 28347269; PubMed Central PMCID: PMC5369006.

Nayak A, Reck A, Morsczeck C, Müller S. Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes. Epigenetics Chromatin. 2017 Mar 23;10:15. doi: 10.1186/s13072-017-0122-8. eCollection 2017. PubMed PMID: 28344658; PubMed Central PMCID: PMC5364561.

Feldmann A, Bekbulat F, Huesmann H, Ulbrich S, Tatzelt J, Behl C, Kern A. The RAB GTPase RAB18 modulates macroautophagy and proteostasis. Biochem Biophys Res Commun. 2017 May 6;486(3):738-743. doi: 10.1016/j.bbrc.2017.03.112. Epub 2017 Mar 22. PubMed PMID: 28342870.

Pampaloni F, Mayer B, Kabat Vel-Job K, Ansari N, Hötte K, Kögel D, Stelzer EHK. A Novel Cellular Spheroid-Based Autophagy Screen Applying Live Fluorescence Microscopy Identifies Nonactin as a Strong Inducer of Autophagosomal Turnover. SLAS Discov. 2017 Jun;22(5):558-570. doi: 10.1177/2472555217696798. Epub 2017 Mar 15. PubMed PMID: 28297606.

Hsieh LT, Nastase MV, Roedig H, Zeng-Brouwers J, Poluzzi C, Schwalm S, Fork C, Tredup C, Brandes RP, Wygrecka M, Huwiler A, Pfeilschifter J, Schaefer L. Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants. Int J Mol Sci. 2017 Mar 9;18(3). pii: E595. doi: 10.3390/ijms18030595. PubMed PMID: 28282921; PubMed Central PMCID: PMC5372611.

Johansen T, Birgisdottir ÅB, Huber J, Kniss A, Dötsch V, Kirkin V, Rogov VV. Methods for Studying Interactions Between Atg8/LC3/GABARAP and LIR-Containing Proteins. Methods Enzymol. 2017;587:143-169. doi: 10.1016/bs.mie.2016.10.023. Epub 2017 Jan 12. PubMed PMID: 28253953.

Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C. Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Elife. 2017 Feb 14;6. pii: e23063. doi: 10.7554/eLife.23063. PubMed PMID: 28195531; PubMed Central PMCID: PMC5323046.

Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I. Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA. Nat Commun. 2017 Jan 13;8:14004. doi: 10.1038/ncomms14004. PubMed PMID: 28084320; PubMed Central PMCID: PMC5241803.

Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR. IKKα controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med. 2017 Feb;214(2):423-437. doi: 10.1084/jem.20161867. Epub 2017 Jan 12. PubMed PMID: 28082356; PubMed Central PMCID: PMC5294863.

Aglan A, Longen S, Dehne N, Köhler Y, Hassan M, Beck M, Tredup C, Boosen M, Hsieh TL, Schaefer L, Beck KF, Pfeilschifter J. Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis. J Mol Med (Berl). 2017 Mar;95(3):257-271. doi: 10.1007/s00109-016-1503-3. Epub 2017 Jan 4. PubMed PMID: 28054119.

2016

Schönbühler B, Schmitt V, Huesmann H, Kern A, Gamerdinger M, Behl C. BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72. Int J Mol Sci. 2016 Dec 30;18(1). pii: E69. doi: 10.3390/ijms18010069. PubMed PMID: 28042827; PubMed Central PMCID: PMC5297704.

Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I. Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. EMBO J. 2017 Feb 15;36(4):549-564. doi: 10.15252/embj.201695063. Epub 2016 Dec 27. PubMed PMID: 28028054; PubMed Central PMCID: PMC5437816.

Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I. Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination. Cell. 2016 Dec 1;167(6):1636-1649.e13. doi: 10.1016/j.cell.2016.11.019. PubMed PMID: 27912065.

Schaefer L, Tredup C, Gubbiotti MA, Iozzo RV. Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. FEBS J. 2017 Jan;284(1):10-26. doi: 10.1111/febs.13963. Epub 2016 Dec 7. Review. PubMed PMID: 27860287; PubMed Central PMCID: PMC5226885.

Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I. SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Elife. 2016 Nov 17;5. pii: e21491. doi: 10.7554/eLife.21491. PubMed PMID: 27852435; PubMed Central PMCID: PMC5127644.

Hoeller D, Dikic I. How the proteasome is degraded. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13266-13268. Epub 2016 Nov 11. PubMed PMID: 27837026; PubMed Central PMCID: PMC5127301.

Beetz N, Rommel C, Schnick T, Neumann E, Lother A, Monroy-Ordonez EB, Zeeb M, Preissl S, Gilsbach R, Melchior-Becker A, Rylski B, Stoll M, Schaefer L, Beyersdorf F, Stiller B, Hein L. Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload. J Mol Cell Cardiol. 2016 Dec;101:145-155. doi: 10.1016/j.yjmcc.2016.10.011. Epub 2016 Oct 24. PubMed PMID: 27789290.

Antonietti P, Linder B, Hehlgans S, Mildenberger IC, Burger MC, Fulda S, Steinbach JP, Gessler F, Rödel F, Mittelbronn M, Kögel D. Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis. Mol Cancer Ther. 2017 Jan;16(1):156-168. doi: 10.1158/1535-7163.MCT-16-0262. Epub 2016 Oct 24. PubMed PMID: 27777286.

Pesic M, Greten FR. Inflammation and cancer: tissue regeneration gone awry. Curr Opin Cell Biol. 2016 Dec;43:55-61. doi: 10.1016/j.ceb.2016.07.010. Epub 2016 Aug 10. Review. PubMed PMID: 27521599.

Kramer P, Jung AT, Hamann A, Osiewacz HD. Cyclophilin D Is Involved in the Regulation of Autophagy and Affects the Lifespan of P. anserina in Response to Mitochondrial Oxidative Stress. Front Genet. 2016 Sep 14;7:165. doi: 10.3389/fgene.2016.00165. eCollection 2016. PubMed PMID: 27683587; PubMed Central PMCID: PMC5021683.

Frey H, Moreth K, Hsieh LT, Zeng-Brouwers J, Rathkolb B, Fuchs H, Gailus-Durner V, Iozzo RV, de Angelis MH, Schaefer L. A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia. Glycoconj J. 2017 Jun;34(3):393-404. doi: 10.1007/s10719-016-9722-y. Epub 2016 Sep 6. PubMed PMID: 27600268.

Weishaupt JH, Hyman T, Dikic I. Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Trends Mol Med. 2016 Sep;22(9):769-783. doi: 10.1016/j.molmed.2016.07.005. Epub 2016 Aug 4. Review. PubMed PMID: 27498188.

Fiskin E, Bionda T, Dikic I, Behrends C. Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection. Mol Cell. 2016 Jun 16;62(6):967-981. doi: 10.1016/j.molcel.2016.04.015. Epub 2016 May 19. PubMed PMID: 27211868.

Behl C. Breaking BAG: The Co-Chaperone BAG3 in Health and Disease. Trends Pharmacol Sci. 2016 Aug;37(8):672-688. doi: 10.1016/j.tips.2016.04.007. Epub 2016 May 6. Review. PubMed PMID: 27162137.

Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4039-44. doi: 10.1073/pnas.1523926113. Epub 2016 Mar 30. PubMed PMID: 27035970; PubMed Central PMCID: PMC4839414.

Jennewein L, Ronellenfitsch MW, Antonietti P, Ilina EI, Jung J, Stadel D, Flohr LM, Zinke J, von Renesse J, Drott U, Baumgarten P, Braczynski AK, Penski C, Burger MC, Theurillat JP, Steinbach JP, Plate KH, Dikic I, Fulda S, Brandts C, Kögel D, Behrends C, Harter PN, Mittelbronn M. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget. 2016 Apr 12;7(15):20016-32. doi: 10.18632/oncotarget.7910. PubMed PMID: 26956048; PubMed Central PMCID: PMC4991435.

Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V. Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation. J Biol Chem. 2016 Apr 22;291(17):9025-41. doi: 10.1074/jbc.M116.715474. Epub 2016 Feb 29. PubMed PMID: 26929408; PubMed Central PMCID: PMC4861472.

Rajalingam K, Dikic I. SnapShot: Expanding the Ubiquitin Code. Cell. 2016 Feb 25;164(5):1074-1074.e1. doi: 10.1016/j.cell.2016.02.019. PubMed PMID: 26919436.

Akutsu M, Dikic I, Bremm A. Ubiquitin chain diversity at a glance. J Cell Sci. 2016 Mar 1;129(5):875-80. doi: 10.1242/jcs.183954. Epub 2016 Feb 15. Review. PubMed PMID: 26906419.

Knuppertz L, Osiewacz HD. Orchestrating the network of molecular pathways affecting aging: Role of nonselective autophagy and mitophagy. Mech Ageing Dev. 2016 Jan;153:30-40. doi: 10.1016/j.mad.2016.01.003. Epub 2016 Jan 24. Review. PubMed PMID: 26814678.

Klionsky DJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 0.1080/15548627.2015.1100356. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PubMed PMID: 26799652; PubMed Central PMCID: PMC4835977.

Philipp O, Osiewacz HD, Koch I. Path2PPI: an R package to predict protein-protein interaction networks for a set of proteins. Bioinformatics. 2016 May 1;32(9):1427-9. doi: 10.1093/bioinformatics/btv765. Epub 2016 Jan 5. PubMed PMID: 26733452; PubMed Central PMCID: PMC4848400.

Antonietti P, Gessler F, Düssmann H, Reimertz C, Mittelbronn M, Prehn JH, Kögel D. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells. Biochim Biophys Acta. 2016 Apr;1863(4):499-509. doi: 10.1016/j.bbamcr.2015.12.016. Epub 2015 Dec 22. PubMed PMID: 26721623.

Hsieh LT, Frey H, Nastase MV, Tredup C, Hoffmann A, Poluzzi C, Zeng-Brouwers J, Manon-Jensen T, Schröder K, Brandes RP, Iozzo RV, Schaefer L. Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis. Matrix Biol. 2016 Jan;49:61-81. doi: 10.1016/j.matbio.2015.12.005. Epub 2015 Dec 12. PubMed PMID: 26689330.

uni-frankfurt.de Georg Speyer Haus Institut für Molekulare Biologie Johannes Gutenberg-Universität Mainz The Max Planck Institute of Biophysics Ludwig-Maximilians-Universität München Eberhard Karls Universität Tübingen Albert-Ludwigs-Universität Freiburg