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2018

ERC Starting Grant for Christian Münch.

27th Jul 2018
The European Research Council (ERC) awarded one of its prestigious Starting Grants to Emmy Noether group leader Christian Münch. The grant provides € 1.44 Mio to carry out a challenging project dubbed ‘mitoUPR’, in which Christian plans to unravel the impact of the mitochondrial unfolded protein response (UPRmt) on the cellular environment in mammalian cells. The UPRmt is a poorly understood mitochondrial stress response that activates upon protein misfolding in mitochondria. Münch’s interest in protein quality control processes dates back to his PhD at University of Cambridge (UK), when he was the first to describe the prion-like behavior of mutant SOD1 in ALS. During his postdoctoral tenure at Harvard University (Boston, USA), he discovered a new branch of the UPRmt controlling mitochondrial translation. Within his ERC project, Christian now plans to analyze how the UPRmt influences processes outside the mitochondrion. According to his central hypothesis, the regulation of cellular stress responses is centrally integrated, and he plans to unravel the role of UPRmt within those signaling networks. A second focus is on mitochondrial RNA granules, which are commonly associated with the organelle’s protein production machinery. Despite the fact that mutations in components of those granules are commonly associated with disease, so far little is known about their architecture and especially their regulation upon stress. To achieve his challenging aims, Christian relies on a range of technologies established at IBC2 and aims at developing an in vivo model for studying the UPRmt.


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Christian Münch joins SFB 1177 as project leader

11th Jul 2018
Recently, the German Research Foundation (DFG) has approved Christian Münch’s supplementary proposal to study Mitophagy induction by the mitochondrial unfolded protein response within the framework of SFB 1177. Protein misfolding in mitochondria has been associated with numerous diseases, including neurodegeneration and cancer, and leads to activation of a mitochondrial stress response – the mitochondrial unfolded protein response (UPRmt). For the next two years, Christian Münch will address the role of mitophagy induction by the UPRmt to resolve mitochondrial protein folding defects.


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Stefan Knapp elected as EMBO member

14th May 2018
The European Molecular Biology Organization (EMBO) announces the list of 62 scientists who were elected as members in 2018. Amongst them is Prof. Stefan Knapp, project leader within SFB 1177, therewith joining "a group of more than 1800 of the best researchers in Europe and around the world“, as EMBO states.

EMBO press release Link
EMBO profile of Stefan Knapp Link


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2017

Autophagosomal content profiling reveals novel mitophagy pathway

16th Nov 2017
Until now, little was known about the identity of proteins which are disposed via autophagy. In an unbiased approach to shed light on this conundrum, the Behrends group used a novel proteomics technology to selectively capture all cargo proteins carried by autophagosomes in living cells. The outcome was a long list of 1,147 proteins – amongst them numerous involved in mitochondrial function, a rather unexpected result considering that no treatment triggering mitophagy was applied. The researchers followed up on this and made a yet more surprising discovery: They found that proteins from several mitochondrial subcompartments are directed towards autophagosomes in a piecemeal fashion, meaning without degradation of the entire organelle. This establishes a novel mechanism of mitophagy, which may function to maintain the mitochondrial household under basal growth condition. The study was largely funded by the CRC 1177 (www.sfb1177.de) and carried out at IBC2 and at Ludwig-Maximilians-Universität (LMU) München, to where the Behrends lab recently moved. The results are published in today’s issue of Molecular Cell.


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RTN3 identified as novel ER-phagy receptor.

15th Jun 2017
The endoplasmic reticulum (ER) is the cell’s largest and probably most versatile organelle. It consists of extended membrane structures, which are constantly remodeled to ensure functionality in all cellular states. Degradation of the ER is mediated by a specialized form of selective autophagy (ER-phagy), a process which is until now not very well understood. An international team around Ivan Dikic has identified Reticulon 3 (the full-length form of RTN3) as a selective receptor which specifically triggers fragmentation of ER tubules and their delivery to lysosomes. The process requires the core autophagy machinery but is independent of FAM134B, the first ER-phagy receptor previously identified by Dikic’s group. FAM134B is responsible for targeting ER sheets rather than ER tubules. The scientists were surprised to discover that the full length RTN3 contains six of the so called LIR motifs that are essential for the function of autophagy receptor. Normally, a single LIR motif is sufficient. Most likely, the high amount of LIR motifs leads to a positive amplification loop. The experiments also enabled a broader view on different roles of the RTN protein family, highlighting the importance of discriminating between isoforms which display highly specialized and unique functions. The results have now been published online in eLife (Grumati et al, 2017).

Link to Original article

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BUILD.FUTURE.NOW.

15th May 2017
This was the slogan of a public TEDx event in Zagreb, at which IBC2 director Ivan Dikic shared his thoughts about what can be learnt from bacteria. It was the largest Croatian TED event ever, full of enthusiasm, creativity and inspiration. The 20 speakers came from many different areas of society, and all gave one major motivation message: boundaries can be broken if we just strive hard enough. „It was an amazing event, positive and vibrant. The moment when you step out on stage is almost electrifying“, described Ivan Dikic his appearance in the Lisinski Concert Hall which was filled with an audience of 1000. TED is a non-profit organization devoted to spreading great ideas around the globe, TEDx events are independently organized, but follow the same mission of helping communities to spark conversation and connection

Link to picture gallery.
Link to TEDxZagreb.
Link to TED.
Link to the video on Youtube
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Linear ubiquitination controls Salmonella growth

8th May 2017
A team around Ivan Dikic and Mike Heilemann (Chemistry Department, Goethe University) gained unprecedented insight into the mechanism by which cells fight Salmonella infections. Upon intracellular invasion, bacteria are usually rapidly surrounded by a coat of ubiquitin, the function of which remained unclear until now. Combining super-resolution microscopy with cell biological analysis, the researchers now discovered that distinct ubiquitin chains transform the bacterial surface into a molecular signalling platform. They were able to visualize the nanoscale distribution of different ubiquitin chains on the bacterial surface. One chain type, so called linear chains, specifically triggers pro-inflammatory signalling cascades, thereby restricting bacterial proliferation. In addition, the researchers identified the deubiquitinase OTULIN as a regulator capable of limiting this reaction – a very important notion considering the fact that excessive inflammation is one of the major causes of tissue damage following bacterial infection. In collaboration with colleagues from Japan, the Frankfurt researchers now published their results in the latest online issue of Nature Microbiology. Their work is an excellent example for interdisciplinary collaboration and was enabled by funding of several large research networks, e.g. the Cluster of Excellence Macromolecular Complexes, the CRC 1177 on selective autophagy and the LOEWE ubiquitin network. The discovery paves the way for many new projects. Very recently, Ivan Dikic obtained one of the prestigious ERC Advanced Grants in which he will investigate the role of ubiquitin in modulating the host-pathogen interaction in more detail.
Link to publication.
Link to German press release.
Link to English press release.


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How Salmonella tricks the immune system.

13th Jan 2017
Infections with bacterial pathogens represent a global burden and are a major cause of death worldwide. For the design of new treatment paradigms it is essential to understand the intricate interplay between bacterial virulence strategies and host defense. The Dikic laboratory now added the next piece to the puzzle: They elucidated how the Salmonella effector enzyme SopA, a HECT-like E3 ligase, targets two host proteins involved in activating the immune defense (TRIM56 and TRIM65) and triggers their degradation. Atomic details of this new mechanism have now been published in Nature Communications and give a detailed insight into how Salmonella increases its own infectivity by interfering with the host immune response.


Link to publication
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Registration still open: 30th ENCP Congress, September 2nd - 5th, 2017, Paris, France

Symposium on Neuronal Autophagy
SFB 1177 vice speaker Christian Behl will be chairing the symposium „Neuronal autophagy: Concepts and treatment options“ at the 30th ENCP Congress (September 2nd - 5th, 2017, Paris, France).
Registration details and more information
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Fluorescence-based sensors for specifically monitoring autophagy

6th February 2017
Autophagy is a cellular recycling and quality control pathway that is essential for maintaining cellular metabolism and homeostasis. Its malfunction contributes e.g. to neurodegenerative diseases and cancer.
Ubiquitin-like ATG8 proteins constitute central components of the autophagic machinery. However, until today, it is not completely clear why yeast harbors only one ATG8 protein while human cells contain six mammalian ATG8 orthologs, classified into the LC3 and GABARAP subfamilies. Using an interdisciplinary approach combining phage display with additional functional biochemical assays as well as cellular biology, the laboratories of Ivan Dikic and Andreas Ernst now engineered a valuable tool for studying specific functions of LC3 and GABARAP proteins. They developed fluorescence-based sensors that are able to discriminate between the six different members of the mammalian ATG8 protein family and track their actions within cells. As first application, the scientists successfully monitored the involvement of LC3C in selective autophagy of mitochondria (mitophagy) and Salmonella (xenophagy). The joint effort of the Dikic and Ernst groups has been published recently in EMBO Journal and will be helpful in decoding biological functions of individual LC3/GABARAP proteins.
Link to publication.
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2016

Autophagy captures the Nobel Prize.

10th Dec 2016
This year’s Nobel Essay in Cell has been written by Ivan Dikic (IBC2) together with Sharon Tooze (Francis Crick Institute, London). Published on time for the Nobel Ceremony on 10th December, the article highlights milestones leading to the discovery of the molecular principles underlying autophagy by Yoshinori Ohsumi, who is this years’ winner of the Nobel Prize for Medicine or Physiology. Dikic and Tooze tell the story of a simple yet insightful yeast genetic screen that revealed what later was recognized to be one of the most powerful quality-control pathways in cells.


Link to essay in Cell.
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New ubiquitin chemistry regulates life processes

1st December 2016
In the latest issue of Cell, a team around IBC2 director and SFB 1177 speaker Ivan Dikic reveals molecular details of a novel ubiquitination mechanism that may affect numerous life processes. Earlier this year, U.S. colleagues reported that Legionella enzyme SdeA is capable of catalysing ubiquitination single-handedly. Now, the Frankfurt scientists together with collaborators from the MPI for Biology of Ageing (Cologne) have elucidated the chemistry behind and discovered a hitherto unknown type of linkage between ubiquitin and target proteins. Unlike the conventional ubiquitination reaction, the novel one is NAD-dependent, involving an ADP-ribose intermediate and resulting in the attachment of ubiquitin to substrate serine residues via a phosphodiester bond.
While those findings alone are breaking new ground, the discovery went even further: The team showed that the Legionella enzyme does not only transfer ubiquitin onto target proteins, but also leaves behind a complete pool of chemically modified, phosphoribosylated ubiquitin. Phosphoribosylated ubiquitin almost completely inhibits the conventional ubiquitination system and thereby affects essential cellular processes, e.g. proteasomal protein degradation, mitophagy and pro-inflammatory signalling. This explains the pathogenic effects of Legionella infection in immunocompromised patients, who often suffer from extensive lung tissue damage despite antibiotic treatment. The insight generated by the Dikic team may now open the road to the development of new antibacterial agents, which could complement conventional antibiotics by limiting the cellular damage induced by bacterial enzymes.
Link to Cell paper.
Link to German press release.
Link to English press release.
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International marketing concept of UBAUT networks receives DFG award

1st December 2016
As the German Research Foundation (DFG) announced today, Goethe University (GU) is one of the winners of the 2016 Competition for International Research Marketing Ideas. The awarded concept “Let’s talk about UBAUT” was initiated by SFB 1177 on Autophagy (http://www.sfb1177.de), LOEWE Ub-Net (LINK TO http://www.proloewe.de/ubnet) and IBC2, and in collaboration with GU’s Departments for Internationalization and Marketing and Communication. The prize is awarded with 100,000 €, enabling the ubiquitin and autophagy networks now to implement a wide range of marketing measures for increasing their international visibility and attract highly qualified international colleagues to the Rhine Main biomedical research area. The program follows a ‘bottom-up’ approach which will be driven by LOEWE Ub-Net and SFB 1177 scientists. It comprises ambassador visits to renowned research institutions in the US as well as short stipends for international scientists wishing to pursue a career in Germany and a strategy outreach meeting.
Link to DFG press release.
Link to GU press release.
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Nobel Prize in Physiology or Medicine 2016 for autophagy researcher: Congratulations to Yoshinori Ohsumi

3rd October 2016
The Nobel Assembly at Karolinska Institutet decided today that the 2016 Prize is awarded to Yoshinori Ohsumi for his discoveries of mechanisms for autophagy. The Japanese scientist is considered as the founding father of autophagy research: He identified the first autophagy genes in yeast, elucidated the underlying mechanisms and showed that a similar sophisticated machinery exists in human cells. Ohsumi holds a professorship at the Tokyo Institute of Technology in Japan. He is the only Laureate receiving the prize this year, underlining the significance and breakthrough character of his discoveries. The announcement came as fantastic news for the entire field of autophagy research, and the SFB 1177 consortium sends sincerest congratulations to Yoshinori Ohsumi.
Link to the Nobel Academy Press Release
Link to ZDF heute journal report including statement from SFB 1177 member Simone Fulda

 

SFB 1177 practical course on autophagy

August 2016
The practical course on autophagy, organized by SFB 1177 group leaders Christian Behrends and Christian Pohl, conveyed hands-on experience in autophagy research. In five days, the participants employed biochemical and cell biological assays to study the autophagy pathway and expanded their knowledge on model organisms such as C. elegans as well as on technologies like mass spectrometry and gene editing with CRISPR/Cas9. Daily lectures by senior scientists and group leaders complemented the practical focus of the workshop. By presenting their own preliminary data, both PhD students and Postdocs gained valuable insights into the currently running projects within SFB 1177, sowing the seeds for new collaborations amongst the members of the SFB graduate school. Thanks to all participants for creating a highly supportive and interactive atmosphere fostering the exchange of many experiences and advices!
More info

 

Frankfurt Conference on Ubiquitin and Autophagy – thanks to all speakers and participants

8th July 2016
From July 4th to 7th, 2016, leading experts in Ubiquitin and Autophagy research from around the world were brought together at Goethe University’s Medical Campus for the first Frankfurt Conference on Ubiquitin and Autophagy, jointly organized by the Cluster of Excellence Macromolecular Complexes, the DKTK site Frankfurt/Mainz, the LOEWE program Ub-Net and SFB 1177. Since the ubiquitin system and autophagy are essential for maintaining cellular integrity and homeostasis, and defects in the two quality control systems are involved in the pathogenesis of numerous diseases, the meeting put emphasis on gaining a more global view on cellular quality control mechanisms, their interconnectivities as well as on exploiting the potential for therapeutic interventions. More than 300 scientists from 12 countries attended the meeting and almost 50 talks in five interdisciplinary sessions covered a broad range of topics from the discovery of basic molecular mechanisms to translation into clinical applications. Moreover, the contribution by early career researchers in vivid discussions and more than 110 poster presentations was overwhelming, as was the quality of the work presented. Coffee breaks, welcome reception and a farewell barbecue at Goethe University’s Westend Campus with a view on the impressive Frankfurt skyline fostered the exchange and interaction amongst the participants giving rise to new ideas, collaborations and insights. The organizers would like to thank all speakers and participants for their active and valuable contribution to the meeting and look forward to the next Frankfurt Conference in 2018.

Interested in Alzheimer’s - register here: "Beyond Amyloid - Widening the View on Alzheimer's Disease“

Herrenhausen Symposium, October 10 & 11 in Hanover, Germany.
Hosted as a Herrenhausen Symposium by the Volkswagen Foundation the meeting aims at bringing together current knowledge on molecular and cellular processes that contribute to AD pathogenesis beyond the so far dominating amyloid hypothesis and at fostering discussion on future perspectives in AD research. Topics to be covered include inflammation, vascular dysfunction, mitochondrial integrity, cell cycle events, lipid metabolism, tau biochemistry, protein misfolding and autophagy. There are no fees to attend the symposium but registration is required.
More info
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Adolf Messer-Stiftungspreis for Anja Bremm.

30th June 2016
Dr. Anja Bremm, group leader of the Molecular Cell Biology Group at IBC2 and Buchmann Institute for Life Sciences (BMLS) was awarded the 2016 Adolf Messer-Stiftungspreis for her research on the physiological role of deubiquitinases (DUBs) in autophagy, endowed by the Adolf Messer Foundation. Stefan Müller, professor of IBC2, held the laudatory speech at the official award ceremony on June 30th, 2016. The prize is conferred annually to early career scientists with an outstanding proven track record to promote pioneering fundamental research projects in natural sciences and medicine and is remunerated with 25.000 €.


Link to Anja Bremm’s research group
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Boehringer Ingelheim Foundation awards Christian Behrends.

14th Apr 2016
Dr. Christian Behrends, group leader of the Autophagy Signaling Group at the IBC2 and part of the SFB 1177 on Selective Autophagy has been selected to be a PLUS3 fellow of the Boehringer Ingelheim Foundation. The foundation will fund his research with a generous support of around 900.000 € for the next three years.


Link to Christian Behrends Lab
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Shedding light on ALS: Novel mechanism in selective autophagy discovered.

29th Mar 2016
ALS (Amyotrophic lateral sclerosis) is a rare and severe disease characterized by loss of motor neurons and neurodegeneration leading to death within 3-4 years. The 2014 ice bucket challenge brought ALS to broader public attention but to date there is no treatment for ALS, despite intensive research in the field. After being involved in the discovery of a kinase (Tank-binding kinase 1, TBK1) linked to ALS (Freischmidt el al., nature neuroscience 2015), researchers from the IBC2 in collaboration with international partners now succeeded in clarifying the physiological function of TBK1. The group around Ivan Dikic revealed that TBK1 specifically phosphorylates its adaptor protein optineurin, thereby enabling a stronger binding of optineurin to ubiquitin that marks damaged mitochondria. By this means, TBK1 promotes an important cellular quality control system responsible for the clearance of damaged mitochondria and other cellular organelles, a process called selective autophagy. Damaged mitochondria, TBK1 and optineurin have long been linked to neurodegenerative diseases such as Parkinson’s and ALS. However, the molecular details behind this connection are only beginning to be unveiled. Benjamin Richter, first author of the study, and his colleagues could further show that an ALS-associated TBK1 mutant fails to associate with optineurin and damaged mitochondria representing a possible link to the disease mechanism underlying ALS. The results are published in this weeks’ PNAS Online Early Edition.


Link to full text article
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Registration open now – Frankfurt Conference on Ubiquitin and Autophagy, July 4-7, 2016

January 2016
Together with the Cluster of Excellence Macromolecular Complexes, the SFB 1177, and the DKTK Frankfurt, LOEWE Ub-Net is organizing the first Frankfurt Conference on Ubiquitin and Autophagy in July 2016. Both the ubiquitin system and autophagy are essential for maintaining cellular integrity and homeostasis. Defects in the two quality control systems are involved in the pathogenesis of numerous diseases. The conference brings together leading experts in this field. Further information and registration here.
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2015

DFG funds autophagy research network

20th Nov 2015
Scientists from Frankfurt and Mainz have successfully applied for funding to establish a Collaborative Research Centre (CRC)/Sonderforschungsbereich (SFB) on the molecular mechanisms of selective autophagy. Autophagy literally means „self-eating“ and describes a process by which the cell recycles harmful ballast like aggregated proteins, damaged organelles or even bacterial invaders. For the next four years, the centre is funded by the German Research Foundation (DFG) with 11 M €. The initiative is led by Ivan Dikic, and is the first large-scale collaborative network in Germany in this highly competitive field.
In the newly established CRC, researchers from the Goethe University, the University Medical Centre in Mainz, the Georg-Speyer-Haus in Frankfurt and the Institute of Molecular Biology in Mainz have teamed up to characterize selective autophagy on the molecular and functional level. This will eventually lead to a better understanding of the role of autophagy in pathophysiology and pave the road for innovative, targeted therapies.
The funding by the DFG will now give a powerful impetus for the network, also strengthening the position of the Rhine Main scientists on the international stage.
Link to German press release.

 

 

2016

Interview with Christian Behrends, project leader in SFB 1177

October 2016

Journal of Cell Science JCS interview


 

2018

 

Di Rita A, Peschiaroli A, D Acunzo P, Strobbe D, Hu Z, Gruber J, Nygaard M, Lambrughi M, Melino G, Papaleo E, Dengjel J, El Alaoui S, Campanella M, Dötsch V, Rogov VV, Strappazzon F, Cecconi F. HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα. Nat Commun. 2018 Sep 14;9(1):3755. doi: 10.1038/s41467-018-05722-3. PubMed PMID: 30217973; PubMed Central PMCID: PMC6138665.

 

Kniss A, Kazemi S, Löhr F, Berger M, Rogov VV, Güntert P, Sommer T, Jarosch E, Dötsch V. Structural investigation of glycan recognition by the ERAD quality control lectin Yos9. J Biomol NMR. 2018 Jul 31. doi: 10.1007/s10858-018-0201-6. [Epub ahead of print] PubMed PMID: 30066206.

 

Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, Münch C, Behrends C, Kögel D. AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy. 2018;14(10):1693-1709. doi: 10.1080/15548627.2018.1476812. Epub 2018 Jul 21. PubMed PMID: 29938581; PubMed Central PMCID: PMC6135628.

 

Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM. A multiprotein supercomplex controlling oncogenic signalling in lymphoma. Nature. 2018 Aug;560(7718):387-391. doi: 10.1038/s41586-018-0290-0. Epub 2018 Jun 20. PubMed PMID: 29925955.

 

Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR. Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. Cell. 2018 Jun 28;174(1):88-101.e16. doi: 10.1016/j.cell.2018.05.028. Epub 2018 Jun 14. PubMed PMID: 29909986.

 

Kern A, Spang N, Huesmann H, Behl C. Novel Modulators of Proteostasis: RNAi Screen of Chromosome I in a Heat Stress Paradigm in C. elegans. Cells. 2018 May 26;7(6). pii: E49. doi: 10.3390/cells7060049. PubMed PMID: 29861461; PubMed Central PMCID: PMC6025327.

 

Roedig H, Nastase MV, Frey H, Moreth K, Zeng-Brouwers J, Poluzzi C, Hsieh LT, Brandts C, Fulda S, Wygrecka M, Schaefer L. Biglycan is a new high-affinity ligand for CD14 in macrophages. Matrix Biol. 2018 May 17. pii: S0945-053X(18)30186-0. doi: 10.1016/j.matbio.2018.05.006. [Epub ahead of print] PubMed PMID: 29777767.

 

Harwardt MIE, Dietz MS, Heilemann M, Wohland T. SPT and Imaging FCS Provide Complementary Information on the Dynamics of Plasma Membrane Molecules. Biophys J. 2018 May 22;114(10):2432-2443. doi: 10.1016/j.bpj.2018.03.013. Epub 2018 Apr 9. PubMed PMID: 29650369; PubMed Central PMCID: PMC6129459.

 

Dikic I, Elazar Z. Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364. doi: 10.1038/s41580-018-0003-4. Review. PubMed PMID: 29618831.

 

Kunz K, Piller T, Müller S. SUMO-specific proteases and isopeptidases of the SENP family at a glance. J Cell Sci. 2018 Mar 20;131(6). pii: jcs211904. doi: 10.1242/jcs.211904. Review. PubMed PMID: 29559551.

 

Fulda S. Targeting autophagy for the treatment of cancer. Biol Chem. 2018 Jun 27;399(7):673-677. doi: 10.1515/hsz-2018-0105. PubMed PMID: 29500917.

 

Heidelberger JB, Voigt A, Borisova ME, Petrosino G, Ruf S, Wagner SA, Beli P. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. EMBO Rep. 2018 Apr;19(4). pii: e44754. doi: 10.15252/embr.201744754. Epub 2018 Feb 21. PubMed PMID: 29467282; PubMed Central PMCID: PMC5891417.

 

Das CK, Linder B, Bonn F, Rothweiler F, Dikic I, Michaelis M, Cinatl J, Mandal M, Kögel D. BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells. Neoplasia. 2018 Mar;20(3):263-279. doi: 10.1016/j.neo.2018.01.001. Epub 2018 Feb 22. PubMed PMID: 29462756; PubMed Central PMCID: PMC5852393.

 

Kniss A, Schuetz D, Kazemi S, Pluska L, Spindler PE, Rogov VV, Husnjak K, Dikic I, Güntert P, Sommer T, Prisner TF, Dötsch V. Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains. Structure. 2018 Feb 6;26(2):249-258.e4. doi: 10.1016/j.str.2017.12.011. Epub 2018 Jan 18. PubMed PMID: 29358025.

 

Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte-Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F. Guidelines and recommendations on yeast cell death nomenclature. Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review. PubMed PMID: 29354647; PubMed Central PMCID: PMC5772036.

 

Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, Schaefer L. Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity. J Histochem Cytochem. 2018 Apr;66(4):213-227. doi: 10.1369/0022155417740880. Epub 2018 Jan 1. PubMed PMID: 29290139; PubMed Central PMCID: PMC5958376.

 

Nastase MV, Janicova A, Roedig H, Hsieh LT, Wygrecka M, Schaefer L. Small Leucine-Rich Proteoglycans in Renal Inflammation: Two Sides of the Coin. J Histochem Cytochem. 2018 Apr;66(4):261-272. doi: 10.1369/0022155417738752. Epub 2018 Jan 1. PubMed PMID: 29290137; PubMed Central PMCID: PMC5958374.

 

2017

 

Nastase MV, Zeng-Brouwers J, Wygrecka M, Schaefer L. Targeting renal fibrosis: Mechanisms and drug delivery systems. Adv Drug Deliv Rev. 2018 Apr;129:295-307. doi: 10.1016/j.addr.2017.12.019. Epub 2017 Dec 27. Review. PubMed PMID: 29288033.

 

Nastase MV, Zeng-Brouwers J, Beckmann J, Tredup C, Christen U, Radeke HH, Wygrecka M, Schaefer L. Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney. Matrix Biol. 2018 Aug;68-69:293-317. doi: 10.1016/j.matbio.2017.12.002. Epub 2017 Dec 15. PubMed PMID: 29253517.

 

Grumati P, Dikic I. Ubiquitin signaling and autophagy. J Biol Chem. 2018 Apr 13;293(15):5404-5413. doi: 10.1074/jbc.TM117.000117. Epub 2017 Nov 29. Review. PubMed PMID: 29187595; PubMed Central PMCID: PMC5900779.

 

Le Guerroué F, Eck F, Jung J, Starzetz T, Mittelbronn M, Kaulich M, Behrends C. Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell. 2017 Nov 16;68(4):786-796.e6. doi: 10.1016/j.molcel.2017.10.029. PubMed PMID: 29149599.

 

Jung J, Behrends C. Protocol for Establishing a Multiplex Image-based Autophagy RNAi Screen in Cell Cultures. Bio Protoc. 2017 Sep 5;7(17):27982478. doi: 10.21769/BioProtoc.2540. PubMed PMID: 28966949; PubMed Central PMCID: PMC5619641.

 

Varga J, Greten FR. Cell plasticity in epithelial homeostasis and tumorigenesis. Nat Cell Biol. 2017 Oct;19(10):1133-1141. doi: 10.1038/ncb3611. Epub 2017 Sep 25. Review. PubMed PMID: 28945230.

 

Harwardt MIE, Young P, Bleymüller WM, Meyer T, Karathanasis C, Niemann HH, Heilemann M, Dietz MS. Membrane dynamics of resting and internalin B-bound MET receptor tyrosine kinase studied by single-molecule tracking. FEBS Open Bio. 2017 Aug 29;7(9):1422-1440. doi: 10.1002/2211-5463.12285. eCollection 2017 Sep. PubMed PMID: 28904870; PubMed Central PMCID: PMC5586345.

 

Henkel V, Warnsmann V, Osiewacz HD. Autophagic responses compensate mitochondrial impairments. Aging (Albany NY). 2017 Sep 12;9(9):1947-1948. doi: 10.18632/aging.101292. PubMed PMID: 28904241; PubMed Central PMCID: PMC5636663.

 

Aguilera-Gomez A, Zacharogianni M, van Oorschot MM, Genau H, Grond R, Veenendaal T, Sinsimer KS, Gavis EA, Behrends C, Rabouille C. Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation. Cell Rep. 2017 Aug 29;20(9):2277. doi: 10.1016/j.celrep.2017.08.054. PubMed PMID: 28854374.

 

Schwalm S, Beyer S, Frey H, Haceni R, Grammatikos G, Thomas D, Geisslinger G, Schaefer L, Huwiler A, Pfeilschifter J. Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction. Am J Pathol. 2017 Nov;187(11):2413-2429. doi: 10.1016/j.ajpath.2017.06.017. Epub 2017 Aug 12. PubMed PMID: 28807595.

 

Reilly R, Mroz MS, Dempsey E, Wynne K, Keely SJ, McKone EF, Hiebel C, Behl C, Coppinger JA. Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis. Sci Rep. 2017 Aug 9;7(1):7642. doi: 10.1038/s41598-017-06588-z. PubMed PMID: 28794469; PubMed Central PMCID: PMC5550428.

 

Wiechmann S, Gärtner A, Kniss A, Stengl A, Behrends C, Rogov VV, Rodriguez MS, Dötsch V, Müller S, Ernst A. Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation. J Biol Chem. 2017 Sep 15;292(37):15340-15351. doi: 10.1074/jbc.M117.794255. Epub 2017 Aug 7. PubMed PMID: 28784659; PubMed Central PMCID: PMC5602394.

 

Polajnar M, Dietz MS, Heilemann M, Behrends C. Expanding the host cell ubiquitylation machinery targeting cytosolic Salmonella. EMBO Rep. 2017 Sep;18(9):1572-1585. doi: 10.15252/embr.201643851. Epub 2017 Aug 6. PubMed PMID: 28784601; PubMed Central PMCID: PMC5579355.

 

Jung J, Behrends C. Multifaceted role of SMCR8 as autophagy regulator. Small GTPases. 2017 Jul 11:1-9. doi: 10.1080/21541248.2017.1346553. [Epub ahead of print] PubMed PMID: 28696821.

 

Warnsmann V, Meyer N, Hamann A, Kögel D, Osiewacz HD. A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction. Mech Ageing Dev. 2018 Mar;170:45-58. doi: 10.1016/j.mad.2017.06.004. Epub 2017 Jul 3. PubMed PMID: 28684269.

 

Stürner E, Behl C. The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease. Front Mol Neurosci. 2017 Jun 21;10:177. doi: 10.3389/fnmol.2017.00177. eCollection 2017. Review. PubMed PMID: 28680391; PubMed Central PMCID: PMC5478690.

 

Rogov VV, Stolz A, Ravichandran AC, Rios-Szwed DO, Suzuki H, Kniss A, Löhr F, Wakatsuki S, Dötsch V, Dikic I, Dobson RC, McEwan DG. Structural and functional analysis of the GABARAP interaction motif (GIM). EMBO Rep. 2017 Aug;18(8):1382-1396. doi: 10.15252/embr.201643587. Epub 2017 Jun 27. PubMed PMID: 28655748; PubMed Central PMCID: PMC5538626.

 

Grumati P, Morozzi G, Hölper S, Mari M, Harwardt MI, Yan R, Müller S, Reggiori F, Heilemann M, Dikic I. Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy. Elife. 2017 Jun 15;6. pii: e25555. doi: 10.7554/eLife.25555. PubMed PMID: 28617241; PubMed Central PMCID: PMC5517149.

 

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G. Molecular definitions of autophagy and related processes. EMBO J. 2017 Jul 3;36(13):1811-1836. doi: 10.15252/embj.201796697. Epub 2017 Jun 8. Review. PubMed PMID: 28596378; PubMed Central PMCID: PMC5494474.

 

Nastase MV, Janicova A, Wygrecka M, Schaefer L. Signaling at the Crossroads: Matrix-Derived Proteoglycan and Reactive Oxygen Species Signaling. Antioxid Redox Signal. 2017 Oct 20;27(12):855-873. doi: 10.1089/ars.2017.7165. Epub 2017 Jul 5. Review. PubMed PMID: 28510506.

 

van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I. Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation. Nat Microbiol. 2017 May 8;2:17066. doi: 10.1038/nmicrobiol.2017.66. PubMed PMID: 28481361. Dikic I. Proteasomal and Autophagic Degradation Systems. Annu Rev Biochem. 2017 Jun 20;86:193-224. doi: 10.1146/annurev-biochem-061516-044908. Epub 2017 May 1. Review. PubMed PMID: 28460188.

 

Knuppertz L, Osiewacz HD. Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan. Aging Cell. 2017 Aug;16(4):704-715. doi: 10.1111/acel.12600. Epub 2017 Apr 27. PubMed PMID: 28449241; PubMed Central PMCID: PMC5506401.

 

Rogov VV, Suzuki H, Marinković M, Lang V, Kato R, Kawasaki M, Buljubašić M, Šprung M, Rogova N, Wakatsuki S, Hamacher-Brady A, Dötsch V, Dikic I, Brady NR, Novak I. Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins. Sci Rep. 2017 Apr 25;7(1):1131. doi: 10.1038/s41598-017-01258-6. PubMed PMID: 28442745; PubMed Central PMCID: PMC5430633.

 

Knuppertz L, Warnsmann V, Hamann A, Grimm C, Osiewacz HD. Stress-dependent opposing roles for mitophagy in aging of the ascomycete Podospora anserina. Autophagy. 2017 Jun 3;13(6):1037-1052. doi: 10.1080/15548627.2017.1303021. Epub 2017 Apr 3. PubMed PMID: 28368682; PubMed Central PMCID: PMC5486364.

 

Philipp O, Hamann A, Osiewacz HD, Koch I. The autophagy interaction network of the aging model Podospora anserina. BMC Bioinformatics. 2017 Mar 27;18(1):196. doi: 10.1186/s12859-017-1603-2. PubMed PMID: 28347269; PubMed Central PMCID: PMC5369006.

 

Nayak A, Reck A, Morsczeck C, Müller S. Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes. Epigenetics Chromatin. 2017 Mar 23;10:15. doi: 10.1186/s13072-017-0122-8. eCollection 2017. PubMed PMID: 28344658; PubMed Central PMCID: PMC5364561.

 

Feldmann A, Bekbulat F, Huesmann H, Ulbrich S, Tatzelt J, Behl C, Kern A. The RAB GTPase RAB18 modulates macroautophagy and proteostasis. Biochem Biophys Res Commun. 2017 May 6;486(3):738-743. doi: 10.1016/j.bbrc.2017.03.112. Epub 2017 Mar 22. PubMed PMID: 28342870.

 

Pampaloni F, Mayer B, Kabat Vel-Job K, Ansari N, Hötte K, Kögel D, Stelzer EHK. A Novel Cellular Spheroid-Based Autophagy Screen Applying Live Fluorescence Microscopy Identifies Nonactin as a Strong Inducer of Autophagosomal Turnover. SLAS Discov. 2017 Jun;22(5):558-570. doi: 10.1177/2472555217696798. Epub 2017 Mar 15. PubMed PMID: 28297606.

 

Hsieh LT, Nastase MV, Roedig H, Zeng-Brouwers J, Poluzzi C, Schwalm S, Fork C, Tredup C, Brandes RP, Wygrecka M, Huwiler A, Pfeilschifter J, Schaefer L. Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants. Int J Mol Sci. 2017 Mar 9;18(3). pii: E595. doi: 10.3390/ijms18030595. PubMed PMID: 28282921; PubMed Central PMCID: PMC5372611.

 

Johansen T, Birgisdottir ÅB, Huber J, Kniss A, Dötsch V, Kirkin V, Rogov VV. Methods for Studying Interactions Between Atg8/LC3/GABARAP and LIR-Containing Proteins. Methods Enzymol. 2017;587:143-169. doi: 10.1016/bs.mie.2016.10.023. Epub 2017 Jan 12. PubMed PMID: 28253953.

 

Jung J, Nayak A, Schaeffer V, Starzetz T, Kirsch AK, Müller S, Dikic I, Mittelbronn M, Behrends C. Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator. Elife. 2017 Feb 14;6. pii: e23063. doi: 10.7554/eLife.23063. PubMed PMID: 28195531; PubMed Central PMCID: PMC5323046.

 

Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I. Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA. Nat Commun. 2017 Jan 13;8:14004. doi: 10.1038/ncomms14004. PubMed PMID: 28084320; PubMed Central PMCID: PMC5241803.

 

Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR. IKKα controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med. 2017 Feb;214(2):423-437. doi: 10.1084/jem.20161867. Epub 2017 Jan 12. PubMed PMID: 28082356; PubMed Central PMCID: PMC5294863.

 

Aglan A, Longen S, Dehne N, Köhler Y, Hassan M, Beck M, Tredup C, Boosen M, Hsieh TL, Schaefer L, Beck KF, Pfeilschifter J. Nitric oxide mediates prolyl hydroxylase 3 expression in mesangial cells and in glomerulonephritis. J Mol Med (Berl). 2017 Mar;95(3):257-271. doi: 10.1007/s00109-016-1503-3. Epub 2017 Jan 4. PubMed PMID: 28054119.

 

2016

 

Schönbühler B, Schmitt V, Huesmann H, Kern A, Gamerdinger M, Behl C. BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72. Int J Mol Sci. 2016 Dec 30;18(1). pii: E69. doi: 10.3390/ijms18010069. PubMed PMID: 28042827; PubMed Central PMCID: PMC5297704.

 

Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I. Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. EMBO J. 2017 Feb 15;36(4):549-564. doi: 10.15252/embj.201695063. Epub 2016 Dec 27. PubMed PMID: 28028054; PubMed Central PMCID: PMC5437816.

 

Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I. Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination. Cell. 2016 Dec 1;167(6):1636-1649.e13. doi: 10.1016/j.cell.2016.11.019. PubMed PMID: 27912065.

 

Schaefer L, Tredup C, Gubbiotti MA, Iozzo RV. Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology. FEBS J. 2017 Jan;284(1):10-26. doi: 10.1111/febs.13963. Epub 2016 Dec 7. Review. PubMed PMID: 27860287; PubMed Central PMCID: PMC5226885.

 

Lopez-Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic-Terzic I, Terzic J, Dikic I. SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Elife. 2016 Nov 17;5. pii: e21491. doi: 10.7554/eLife.21491. PubMed PMID: 27852435; PubMed Central PMCID: PMC5127644.

 

Hoeller D, Dikic I. How the proteasome is degraded. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13266-13268. Epub 2016 Nov 11. PubMed PMID: 27837026; PubMed Central PMCID: PMC5127301.

 

Beetz N, Rommel C, Schnick T, Neumann E, Lother A, Monroy-Ordonez EB, Zeeb M, Preissl S, Gilsbach R, Melchior-Becker A, Rylski B, Stoll M, Schaefer L, Beyersdorf F, Stiller B, Hein L. Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload. J Mol Cell Cardiol. 2016 Dec;101:145-155. doi: 10.1016/j.yjmcc.2016.10.011. Epub 2016 Oct 24. PubMed PMID: 27789290.

 

Antonietti P, Linder B, Hehlgans S, Mildenberger IC, Burger MC, Fulda S, Steinbach JP, Gessler F, Rödel F, Mittelbronn M, Kögel D. Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis. Mol Cancer Ther. 2017 Jan;16(1):156-168. doi: 10.1158/1535-7163.MCT-16-0262. Epub 2016 Oct 24. PubMed PMID: 27777286.

 

Pesic M, Greten FR. Inflammation and cancer: tissue regeneration gone awry. Curr Opin Cell Biol. 2016 Dec;43:55-61. doi: 10.1016/j.ceb.2016.07.010. Epub 2016 Aug 10. Review. PubMed PMID: 27521599.

 

Kramer P, Jung AT, Hamann A, Osiewacz HD. Cyclophilin D Is Involved in the Regulation of Autophagy and Affects the Lifespan of P. anserina in Response to Mitochondrial Oxidative Stress. Front Genet. 2016 Sep 14;7:165. doi: 10.3389/fgene.2016.00165. eCollection 2016. PubMed PMID: 27683587; PubMed Central PMCID: PMC5021683.

 

Frey H, Moreth K, Hsieh LT, Zeng-Brouwers J, Rathkolb B, Fuchs H, Gailus-Durner V, Iozzo RV, de Angelis MH, Schaefer L. A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia. Glycoconj J. 2017 Jun;34(3):393-404. doi: 10.1007/s10719-016-9722-y. Epub 2016 Sep 6. PubMed PMID: 27600268.

 

Weishaupt JH, Hyman T, Dikic I. Common Molecular Pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Trends Mol Med. 2016 Sep;22(9):769-783. doi: 10.1016/j.molmed.2016.07.005. Epub 2016 Aug 4. Review. PubMed PMID: 27498188.

 

Fiskin E, Bionda T, Dikic I, Behrends C. Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection. Mol Cell. 2016 Jun 16;62(6):967-981. doi: 10.1016/j.molcel.2016.04.015. Epub 2016 May 19. PubMed PMID: 27211868.

 

Behl C. Breaking BAG: The Co-Chaperone BAG3 in Health and Disease. Trends Pharmacol Sci. 2016 Aug;37(8):672-688. doi: 10.1016/j.tips.2016.04.007. Epub 2016 May 6. Review. PubMed PMID: 27162137.

 

Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4039-44. doi: 10.1073/pnas.1523926113. Epub 2016 Mar 30. PubMed PMID: 27035970; PubMed Central PMCID: PMC4839414.

 

Jennewein L, Ronellenfitsch MW, Antonietti P, Ilina EI, Jung J, Stadel D, Flohr LM, Zinke J, von Renesse J, Drott U, Baumgarten P, Braczynski AK, Penski C, Burger MC, Theurillat JP, Steinbach JP, Plate KH, Dikic I, Fulda S, Brandts C, Kögel D, Behrends C, Harter PN, Mittelbronn M. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget. 2016 Apr 12;7(15):20016-32. doi: 10.18632/oncotarget.7910. PubMed PMID: 26956048; PubMed Central PMCID: PMC4991435.

 

Habisov S, Huber J, Ichimura Y, Akutsu M, Rogova N, Loehr F, McEwan DG, Johansen T, Dikic I, Doetsch V, Komatsu M, Rogov VV, Kirkin V. Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation. J Biol Chem. 2016 Apr 22;291(17):9025-41. doi: 10.1074/jbc.M116.715474. Epub 2016 Feb 29. PubMed PMID: 26929408; PubMed Central PMCID: PMC4861472.

 

Rajalingam K, Dikic I. SnapShot: Expanding the Ubiquitin Code. Cell. 2016 Feb 25;164(5):1074-1074.e1. doi: 10.1016/j.cell.2016.02.019. PubMed PMID: 26919436.

 

Akutsu M, Dikic I, Bremm A. Ubiquitin chain diversity at a glance. J Cell Sci. 2016 Mar 1;129(5):875-80. doi: 10.1242/jcs.183954. Epub 2016 Feb 15. Review. PubMed PMID: 26906419.

 

Knuppertz L, Osiewacz HD. Orchestrating the network of molecular pathways affecting aging: Role of nonselective autophagy and mitophagy. Mech Ageing Dev. 2016 Jan;153:30-40. doi: 10.1016/j.mad.2016.01.003. Epub 2016 Jan 24. Review. PubMed PMID: 26814678.

 

Klionsky DJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 0.1080/15548627.2015.1100356. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PubMed PMID: 26799652; PubMed Central PMCID: PMC4835977.

 

Philipp O, Osiewacz HD, Koch I. Path2PPI: an R package to predict protein-protein interaction networks for a set of proteins. Bioinformatics. 2016 May 1;32(9):1427-9. doi: 10.1093/bioinformatics/btv765. Epub 2016 Jan 5. PubMed PMID: 26733452; PubMed Central PMCID: PMC4848400.

 

Antonietti P, Gessler F, Düssmann H, Reimertz C, Mittelbronn M, Prehn JH, Kögel D. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells. Biochim Biophys Acta. 2016 Apr;1863(4):499-509. doi: 10.1016/j.bbamcr.2015.12.016. Epub 2015 Dec 22. PubMed PMID: 26721623.

 

Hsieh LT, Frey H, Nastase MV, Tredup C, Hoffmann A, Poluzzi C, Zeng-Brouwers J, Manon-Jensen T, Schröder K, Brandes RP, Iozzo RV, Schaefer L. Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis. Matrix Biol. 2016 Jan;49:61-81. doi: 10.1016/j.matbio.2015.12.005. Epub 2015 Dec 12. PubMed PMID: 26689330.

 

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