Principal Investigators


Image: peoples/csm-tassula-09-17-82b53653e0-1-.png
Prof. Dr. Tassula Proikas-Cezanne

Research Group "Autophagy"
Department of Molecular Biology
Interfaculty Institute for Cell Biology
University of Tuebingen
Auf der Morgenstelle 15
D-72076 Tuebingen, Germany
Office: +49 7071 297 8895
Fax: +49 7071 29 53 59


Molecular functions of WDR45/WlPI4 in ferritinophagy and neurodegeneration

De novo mutations in the WDR45/WIPI4 gene are causative for the human neurodegenerative disease BPAN (beta-propeller associated neurodegeneration). BPAN patients show compromised autophagy and high iron accumulation in the brain. Normally, intracellular iron levels are regulated by ferritinophagy. Since WDR45/WIPI4 functions in autophagic membrane formation, we will now analyze its function in ferritinophagy in the pathophysiological context of BPAN, using control- and patient-derived fibroblasts and iPS cells as well as in vitro differentiated neurons. Georg Speyer Haus Institut für Molekulare Biologie Johannes Gutenberg-Universität Mainz The Max Planck Institute of Biophysics Ludwig-Maximilians-Universität München Eberhard Karls Universität Tübingen Albert-Ludwigs-Universität Freiburg