Steering committee
PUBLICATIONS
2023
González A., Covarrubias-Pinto, A., Bhaskara, R.M., Glogger, M., Kuncha, S.K., Xavier, A., Seemann, E., Misra, M., Hoffmann, M.E., Bräuning, B., Balakrishnan, A., Qualmann, B., Dötsch, V., Schulman, B.A., Kessels, M.M., Hübner, C.A., Heilemann, M., Hummer, G., Dikic, I. (2023) Ubiquitination regulates ER-phagy and remodeling of the endoplasmic reticulum (in press) Nature
Körschgen H, Baeken M, Schmitt D, Nagel H, Behl C. Co-chaperone BAG3 enters autophagic pathway via its interaction with microtubule associated protein 1 light chain 3 beta. Traffic. 2023 Sep 1. doi: 10.1111/tra.12916. Epub ahead of print.
Körschgen H, Behl C. Aggresome-aggrephagy transition process: getting closer to the functional roles of HDAC6 and BAG3. Neural Regeneration Research. 2024 June; 19(6):p 1181-1182. doi: 10.4103/1673-5374.386407
Nalbach, K., Schifferer, M., Bhattacharya, D., Ho-Xuan, H., Tseng, W., Williams, L. A., Stolz, A., Lichtenthaler, S. F., Elazar, Z., & Behrends, C. (2023). Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2. Nature communications, 14(1), 870. https://doi.org/10.1038/s41467-023-36553-6
Pham TNM, Perumal N, Manicam C, Basoglu M, Eimer S, Fuhrmann DC, Pietrzik CU, Clement AM, Körschgen H, Schepers J, Behl C. Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress. Redox Biol. 2023 Nov;67:102943. doi: 10.1016/j.redox.2023.102943. Epub 2023 Oct 20.
Reisbeck L, Linder B, Tascher G, Bozkurt S, Weber KJ, Herold-Mende C, van Wijk SJL, Marschalek R, Schaefer L, Münch C, Kögel D.(2023) The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells. Am J Physiol Cell Physiol. 325(6):C1451-C1469. doi: 10.1152/ajpcell.00293.2023
Sanchez-Martin, P., Kriegenburg, F., Alves, L., Adam, J., Elsaesser, J., Babic, R., Mancilla, H., Licheva, M., Tascher, G., Munch, C., Eimer, S., & Kraft, C. (2023). ULK1-mediated phosphorylation regulates the conserved role of YKT6 in autophagy. J Cell Sci. https://doi.org/10.1242/jcs.260546
Schüssele, D. S., Haller, P. K., Haas, M. L., Hunter, C., Sporbeck, K., & Proikas-Cezanne, T. (2023). Autophagy profiling in single cells with open source CellProfiler-based image analysis. Autophagy, 19(1), 338–351. https://doi.org/10.1080/15548627.2022.2065617
Sutandy, F.X.R., Goessner, I., Tascher, G., Münch, C. (2023). A cytosolic surveillance mechanism activates the mitochondrial UPR. Nature (accepted)
2022
Baeken, M. W., & Behl, C. (2022). On the origin of BAG(3) and its consequences for an expansion of BAG3’s role in protein homeostasis. Journal of cellular biochemistry, 123(1), 102–114. https://doi.org/10.1002/jcb.29925
Bata, N., Chaikuad, A., Bakas, N. A., Limpert, A. S., Lambert, L. J., Sheffler, D. J., Berger, L. M., Liu, G., Yuan, C., Wang, L., Peng, Y., Dong, J., Celeridad, M., Layng, F., Knapp, S., & Cosford, N. D. P. (2022). Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia. Journal of medicinal chemistry, 65(2), 1352–1369. https://doi.org/10.1021/acs.jmedchem.1c00804
Bieber, A., Capitanio, C., Erdmann, PS., Fiedler, F., Beck, F., Lee, CW., Li, D., Hummer, G., Schulman, BA., Baumeister, W., Wilfling, F. (2022). In situ structural analysis reveals membrane shape transitions during autophagosome formation. Proc. Natl. Acad. Sci. U.S.A. 119, e2209823119. https://doi.org/10.1073/pnas.2209823119
Denk, D., Petrocelli, V., Conche, C., Drachsler, M., Ziegler, P. K., Braun, A., Kress, A., Nicolas, A. M., Mohs, K., Becker, C., Neurath, M. F., Farin, H. F., Buchholz, C. J., Andreux, P. A., Rinsch, C., & Greten, F. R. (2022). Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity, 55(11), 2059–2073.e8. https://doi.org/10.1016/j.immuni.2022.09.014
Denk, D., & Greten, F. R. (2022). Inflammation: the incubator of the tumor microenvironment. Trends in cancer, 8(11), 901–914. https://doi.org/10.1016/j.trecan.2022.07.002
Di Lorenzo, G., G., Iavarone, F., Maddaluno, M., Plata-Gómez, A. B., Aureli, S., Quezada Meza, C. P., Cinque, L., Palma, A., Reggio, A., Cirillo, C., Sacco, F., Stolz, A., Napolitano, G., Marin, O., Pinna, L. A., Ruzzene, M., Limongelli, V., Efeyan, A., Grumati, P., & Settembre, C. (2022). Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy. Science Advances, 8 (35). Doi: 10.1126/sciadv.abo1215
Glogger, M., Wang, D., Kompa, J., Balakrishnan, A., Hiblot, J., Barth, H. D., Johnsson, K., & Heilemann, M. (2022). Synergizing Exchangeable Fluorophore Labels for Multitarget STED Microscopy. ACS nano, 16(11), 17991–17997. https://doi.org/10.1021/acsnano.2c07212
Gubas, A., & Dikic, I. (2022a). A guide to the regulation of selective autophagy receptors. FEBS Journal, 289(1), 75–89. https://doi.org/10.1111/febs.15824
Gubas, A., & Dikic, I. (2022b). ER remodeling via ER-phagy. In Molecular Cell (Vol. 82, Issue 8, pp. 1492–1500). Mol Cell. https://doi.org/10.1016/j.molcel.2022.02.018
Hertel, A., Alves, L. M., Dutz, H., Tascher, G., Bonn, F., Kaulich, M., Dikic, I., Eimer, S., Steinberg, F., & Bremm, A. (2022). USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. Cell reports, 41(10), 111653. https://doi.org/10.1016/j.celrep.2022.111653
Jandl, K., Mutgan, A. C., Eller, K., Schaefer, L., & Kwapiszewska, G. (2022). The basement membrane in the cross-roads between the lung and kidney. Matrix Biol, 105, 31-52. https://doi.org/10.1016/j.matbio.2021.11.003
Koschade, S. E., Tascher, G., Parmar, B. S., Brandts, C. H., & Münch, C. (2022). SpinTip: A Simple, Robust, and Versatile Preanalytical Method for Microscale Suspension Cell Proteomics. Journal of proteome research, 21(11), 2827–2835. https://doi.org/10.1021/acs.jproteome.2c00478
Koschade, S. E., Klann, K., Shaid, S., Vick, B., Stratmann, J. A., Thölken, M., Meyer, L. M., Nguyen, T. D., Campe, J., Moser, L. M., Hock, S., Baker, F., Meyer, C. T., Wempe, F., Serve, H., Ullrich, E., Jeremias, I., Münch, C., & Brandts, C. H. (2022). Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia. Leukemia, 36(10), 2396–2407. https://doi.org/10.1038/s41375-022-01678-y
Merline, R., Rodig, H., Zeng-Brouwers, J., Poluzzi, C., Tascher, G., Michaelis, J., Lopez-Mosqueda, J., Rhiner, A., Huber, L. S., Diehl, V., Dikic, I., Kogel, D., Munch, C., Wygrecka, M., & Schaefer, L. (2022). A20 binding and inhibitor of nuclear factor kappa B (NF-kappaB)-1 (ABIN-1) - a novel modulator of mitochondrial autophagy. Am J Physiol Cell Physiol. https://doi.org/10.1152/ajpcell.00493.2022
Michaelis, J. B., Brunstein, M. E., Bozkurt, S., Alves, L., Wegner, M., Kaulich, M., Pohl, C., & Münch, C. (2022). Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy. Nature communications, 13(1), 5164. https://doi.org/10.1038/s41467-022-32564-x
Mukherjee, R., & Dikic, I. (2022). Regulation of Host-Pathogen Interactions via the Ubiquitin System. In Annual review of microbiology (Vol. 76, pp. 211–233). Annu Rev Microbiol. https://doi.org/10.1146/annurev-micro-041020-025803
Remy, J., Linder, B., Weirauch, U., Day, B. W., Stringer, B. W., Herold-Mende, C., Aigner, A., Krohn, K., & Kogel, D. (2022). STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death. Cancers (Basel), 14(2). https://doi.org/10.3390/cancers14020339
Schäfer, J. A., Bozkurt, S., Michaelis, J. B., Klann, K., & Münch, C. (2022). Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery. Molecular cell, 82(2), 435–446.e7. https://doi.org/10.1016/j.molcel.2021.11.004
Schmitt, D., Bozkurt, S., Henning-Domres, P., Huesmann, H., Eimer, S., Bindila, L., Behrends, C., Boyle, E., Wilfling, F., Tascher, G., Münch, C., Behl, C., & Kern, A. (2022). FACS-mediated isolation of native autophagic vesicles. Autophagy. https://doi.org/10.1080/15548627.2022.2151188
Schmitt, D., Bozkurt, S., Henning-Domres, P., Huesmann, H., Eimer, S., Bindila, L., Behrends, C., Boyle, E., Wilfling, F., Tascher, G., Münch, C., Behl, C., & Kern, A. (2022). Lipid and protein content profiling of isolated native autophagic vesicles. EMBO Rep, 23(12): e53065. https://doi.org/10.15252/embr.202153065
Schürmanns, L., Hamann, A., Osiewacz, H.D. (2022). Lifespan increase of Podospora anserina by oleic acid is linked to alterations in energy metabolism, membrane trafficking and autophagy. Cells, 11 (3), 519. doi: 10.3390/cells11030519
Seibert M, Kurrle N, Stolp V, Nuernberger H, Tzschentke S, Boerner L, Wempe F, Serve H, Schnuetgen F (2022) Selection-free endogenous tagging of cell lines by bicistronic co-expression of the surface antigen NGFR. MethodsX. 9:101929. https://doi.org/10.1016/j.mex.2022.101929
Siebert, A., Gattringer, V., Weishaupt, J. H., & Behrends, C. (2022). ALS-linked loss of Cyclin-F function affects HSP90. Life science alliance, 5(12), e202101359. https://doi.org/10.26508/lsa.202101359.
Stelzl, LS., Pietrek, LM., Holla, A., Oroz, J., Sikora, M., Köfinger, J., Schuler, B., Zweckstetter, M., Hummer, G. (2022). Global structure of the intrinsically disordered protein tau emerges from its local structure. JACS Au 2: 673-686. https://doi.org/10.1021/jacsau.1c00536
Strohm, L., Hu, Z., Suk, Y., Rühmkorf, A., Sternburg, E., Gattringer, V., Riemenschneider, H., Berutti, R., Graf, E., Weishaupt, J. H., Brill, M. S., Harbauer, A. B., Dormann, D., Dengjel, J., Edbauer, D., & Behrends, C. (2022). Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants. Life science alliance, 5(11), e202101327. https://doi.org/10.26508/lsa.202101327
Tomaskovic, I., Gonzalez, A. & Dikic, I. (2022). Ubiquitin and Legionella: From bench to bedside. Seminars in Cell and Developmental Biology. https://doi.org/10.1016/J.SEMCDB.2022.02.008
Tiku, V., Kew, C., Kofoed, E. M., Peng, Y., Dikic, I. & Tan, M. W. (2022). Acinetobacter baumannii Secretes a Bioactive Lipid That Triggers Inflammatory Signaling and Cell Death. Frontiers in Microbiology, 13. https://doi.org/10.3389/FMICB.2022.870101/FULL
Warnsmann, V., Marschall, L. M., Meeßen, A. C., Wolters, M., Schürmanns, L., Basoglu, M., Eimer, S., & Osiewacz, H. D. (2022). Disruption of the MICOS complex leads to an aberrant cristae structure and an unexpected, pronounced lifespan extension in Podospora anserina. Journal of cellular biochemistry, 123(8), 1306–1326. https://doi.org/10.1002/jcb.30278
Zhou, D., Borsa, M., Puleston, D. J., Zellner, S., Capera, J., Sanderson, S., Schifferer, M., Hester, S. S., Ge, X., Fischer, R., Jostins, L., Behrends, C., Alsaleh, G., & Simon, A. K. (2022). Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation. Nature communications, 13(1), 5174. https://doi.org/10.1038/s41467-022-32718-x
Heinz D, Krotova E, Hamann A, Osiewacz HD. 2021. Simultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension. Front Cell Dev Biol. vol.9, 259. https://doi.org/10.3389/fcell.2021.616520
2021
Baker, F., Polat, I. H., Abou-El-Ardat, K., Alshamleh, I., Thoelken, M., Hymon, D., Gubas, A., Koschade, S. E., Vischedyk, J. B., Kaulich, M., Schwalbe, H., Shaid, S., & Brandts, C. H. (2021). Metabolic Rewiring Is Essential for AML Cell Survival to Overcome Autophagy Inhibition by Loss of ATG3. Cancers, 13(23), 6142. https://doi.org/10.3390/cancers13236142
Basic, M., Hertel, A., Bajdzienko, J., Bonn, F., Tellechea, M., Stolz, A., Kern, A., Behl, C., & Bremm, A. (2021). The deubiquitinase USP11 is a versatile and conserved regulator of autophagy. The Journal of biological chemistry, 297(5), 101263. https://doi.org/10.1016/j.jbc.2021.101263
Diehl, V., Wegner, M., Grumati, P., Husnjak, K., Schaubeck, S., Gubas, A., Shah, V. J., Polat, I. H., Langschied, F., Prieto-Garcia, C., Müller, K., Kalousi, A., Ebersberger, I., Brandts, C. H., Dikic, I., & Kaulich, M. (2021). Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Nucleic acids research, 49(10), 5684–5704. https://doi.org/10.1093/nar/gkab309
Glogger, M., Spahn, C., Enderlein, J., & Heilemann, M. (2021). Multi-Color, Bleaching-Resistant Super-Resolution Optical Fluctuation Imaging with Oligonucleotide-Based Exchangeable Fluorophores. Angewandte Chemie (International ed. In English), 60(12), 6310–6313. https://doi.org/10.1002/anie.202013166
Hahn, M., Covarrubias-Pinto, A., Herhaus, L., Satpathy, S., Klann, K., Boyle, K. B., Münch, C., Rajalingam, K., Randow, F., Choudhary, C., & Dikic, I. (2021). SIK2 orchestrates actin-dependent host response upon Salmonella infection. Proceedings of the National Academy of Sciences, 118(19). https://doi.org/10.1073/pnas.2024144118
Herhaus L. (2021). TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease. Matrix biology : journal of the International Society for Matrix Biology, 100-101, 84–98. https://doi.org/10.1016/j.matbio.2021.01.004
Heinz, D., Krotova, E., Hamann, A., Osiewacz, H.D. (2021). Simultaneous ablation of the catalytic AMPK -subunit SNF1 and mitochondrial matrix protease CLPP results in pronounced lifespan extension. Front Cell Dev Biol, 9, 259. doi: 10.3389/fcell.2021.616520
Ho, N.T., Siggel, M., Camacho, K.V., Bhaskara, R.M., Hicks, J.M., Yao, Y., Zhang, Y., Köfinger, J., Hummer, G., & Noy, A. (2021). Membrane fusion and drug delivery with carbon nanotube porins. Proc Natl Acad Sci USA,118(19): e2016974118. https://doi.org/10.1073/pnas.2016974118
Juretschke, T., & Beli, P. (2021). Causes and consequences of DNA damage-induced autophagy. Matrix biology : journal of the International Society for Matrix Biology, 100-101, 39–53. https://doi.org/10.1016/j.matbio.2021.02.004.
Liu, Y., Mukherjee, R., Bonn, F., Colby, T., Matic, I., Glogger, M., Heilemann, M., & Dikic, I. (2021). Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection. Cell Death and Differentiation, 28(10), 2957–2969. https://doi.org/10.1038/s41418-021-00830-y
Meyer, N., Henkel, L., Linder, B., Zielke, S., Tascher, G., Trautmann, S., Geisslinger, G., Munch, C., Fulda, S., Tegeder, I., & Kogel, D. (2021). Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy, 17(11), 3424-3443. https://doi.org/10.1080/15548627.2021.1874208
Osiewacz, H.D., Schürmanns, L. (2021). A network of pathways controlling cellular homeostasis affects the onset of senescence in Podospora anserina. J Fungi, 7, 263. doi: 10.3390/jof7040263.
Roedig, J., Kowald, L., Juretschke, T., Karlowitz, R., Ahangarian Abhari, B., Roedig, H., Fulda, S., Beli, P., & van Wijk, S. J. (2021). USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination. EMBO reports, 22(2), e50163. https://doi.org/10.15252/embr.202050163
Schaefer, L., & Dikic, I. (2021). Autophagy: Instructions from the extracellular matrix. Matrix Biol, 100-101, 1-8. https://doi.org/10.1016/j.matbio.2021.06.002
Seibert M, Kurrle N, Schnuetgen F, Serve H (2021) Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation. Matrix Biol. 100-101:65-83. https://doi.org/10.1016/j.matbio.2021.01.001
Siggel, M., Bhaskara, RM., Moesser, MK., Dikic, I., Hummer, G. (2021). FAM134B-RHD protein clustering drives spontaneous budding of asymmetric membranes. J. Phys. Chem. Lett. 2021, 12, 1926-1931. https://doi.org/10.1021/acs.jpclett.1c00031
Warnsmann, V., Marschall, L-M., Osiewacz, H.D.(2021). Impaired F1Fo-ATP-synthase dimerization leads to the induction of cyclophilin D-mediated autophagy-dependent cell death and accelerated aging. Cells, 10, 757. doi: 10.3390/cells10040757
Zellner, S., Schifferer, M., & Behrends, C. (2021). Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling. Molecular cell, 81(6), 1337–1354.e8. https://doi.org/10.1016/j.molcel.2021.01.009
Zein, L., Fulda, S., Kogel, D., & van Wijk, S. J. L. (2021). Organelle-specific mechanisms of drug-induced autophagy-dependent cell death. Matrix Biol, 100-101, 54-64. https://doi.org/10.1016/j.matbio.2020.12.003
Zielke, S., Kardo, S., Zein, L., Mari, M., Covarrubias-Pinto, A., Kinzler, M. N., Meyer, N., Stolz, A., Fulda, S., Reggiori, F., Kogel, D., & van Wijk, S. (2021). ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy, 17(9), 2432-2448. https://doi.org/10.1080/15548627.2020.1827780
2020
Barz S, Kriegenburg F, Henning A, Bhattacharya A, Mancilla H, Sánchez-Martín P, & Kraft C. 2020. Atg1 kinase regulates autophagosome-vacuole fusion by controlling SNARE bundling. EMBO reports, 21(12), e51869.
Eickhorst C, Licheva M, Kraft C. 2020. Scaffold proteins in bulk and selective autophagy. Prog Mol Biol Transl Sci. 2020;172:15-35.
Glogger M, Spahn C, Enderlein J, Heilemann M. 2020. Multi-Color, Bleaching-Resistant Super-Resolution Optical Fluctuation Imaging with Oligonucleotide-based Exchangeable Fluorophores. Angew Chem Int Ed Engl. https://doi.org/10.1002/anie.202013166
Henkel V, Schürmanns L, Brunner M, Hamann A, Osiewacz HD. 2020. Role of sorting nexin PaATG24 in autophagy, aging and development of Podospora anserina. Mech Aging Dev, 186:111211
Hollenstein DM, Kraft C. 2020. Autophagosomes are formed at a distinct cellular structure. Curr Opin Cell Biol. 2020;65:50-57.
Kern A, Behl C. 2020. On-demand autophagic network adaptations upon limited lipid availability. Autophagy, 16:7, 1348-1350
Kinzler MN, Zielke S, Kardo S, Meyer N, Kögel D, van Wijk SJL, Fulda S. 2020. STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts. Sci Rep 10, 687
Kögel D, Linder B, Brunschweiger A, Chines S, Behl C. 2020. At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer. Cells, 9(3), 574.
Steinberg R, Origi A, Natriashvili A, Sarmah P, Licheva M, Walker PM, Kraft C, High S, Luirink J, Shi WQ, Helmstädter M, Ulbrich MH, Koch HG. 2020. Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle. PLoS Biol. 18(9), e3000874.
Wesch N, Kirkin V, Rogov V.V. 2020. Atg8-Family Proteins-Structural Features and Molecular Interactions in Autophagy and Beyond. Cells, 9:9, E2008
Wiechmann S, Maisonneuve P, Grebbin BM, Hoffmeister M, Kaulich M, Clevers H, Rajalingam K, Kurinov I, Farin HF, Sicheri F, Ernst A. 2020. Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J Biol Chem. pii: jbc.RA119.011025.
Zein L, Fulda S, Kögel D, & van Wijk S. 2020. Organelle-specific mechanisms of drug-induced autophagy-dependent cell death. Matrix Biol. https://doi.org/10.1016/j.matbio.2020.12.003
Zielke S, Kardo S, Zein L, Mari M, Covarrubias-Pinto A, Kinzler MN, Meyer N, Stolz A, Fulda S, Reggiori F, Kögel D, van Wijk S. 2020. ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy, 1-17
Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, Ren H, Lambert LJ, Cosford NDP, Brandts CH & Knapp S. 2019. Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Biochem J, 476, 875-887.
Chakraborty D, Felzen V, Hiebel C, Stuerner E, Perumal N, Manicam C, Grus F, Wolfrum U, Behl C. 2019. Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress. Redox Biol, accepted